Imiyalelo yokusebenzisa, analog "Cefotaxime" kunye nohlaziyo

"Cefotaxime" (ezibonisa zokusetyenziswa, imithetho yokubala umthamo ophezulu, kwakunye analogue kakhulu ethandwa ziya kunikwa ngezantsi) yi zintsholongwane semi-zokwenziwa. It iyamelana beta-lactamases kwaye iyasebenza nxamnye zombini gram-HIV kunye gram-elibi iintsholongwane. Indlela asabela ezinto ngenxa kwezithandani ubuchule yeekhomponenti yeenkqubo zendalo ibakho kwiseli inwebu kwamagciwane.

Ichiza ukuba ungene emzimbeni, ngabom utshabalalisa peptidoglycan nokuhlangana limise, kuyimfuneko ukwenzela ukuba iintsholongwane ukuqinisekisa uzinzo kweendonga zendalo. Njengoko yaziwa, izilwa-buhlungu kunye inhibitors izithako iseli mhlaseli elastic - oku kakhulu lula target.

release Form

Le medicament "Cefotaxime" (izitofu manual kunye infusions izipho nje kuphela yesekethe unikezelo into esebenzayo kunokwenzeka) inikezelwa emarikeni zoxubo kwi ngumgubo omhlophe okanye omthubi, leyo isebenza njengesiseko ukulungiselela isisombululo. Oku ekuthiwa-ampoules inaliti.

Yentsusa 10 ezineengqayi ml umthamo eyenziwe ekhanyayo. Elona mass reagent ngoku kwi iyunithi yemveliso enye ixhomekeke ukuzaliswa matrix (0.5, 1.0 okanye 2.0 grams).

isimo pharmacokinetic

Kufuneka ngoko nangoko kuqatshelwe ukuba ayizizo zonke analog "Cefotaxime" liye iipropati pharmacokinetic efanayo njengoko yokuqala. Ngokukodwa, xa sithetha ngayo izinga ukufunxeka yeekhomponenti evela kuyo inaliti, kukufakwa kwezi arhente, ngokwendlela amagqabaza iingcali ezininzi, ngokukhawuleza kakhulu ukufunxeka yokuqala efanayo nangoku "Duataksa" okanye "Tsetaksa". "Ngumkhuba" Isizathu ixhomekeke structured ekuqaleni molecule isampulu. Iingcali e iimpendulo zabo ukugxininisa into yokuba Indian ozingenelayo ngasentla ziquka "ukungcola zamachiza" ngohlobo avela cephalosporin ezinzima leyo ukucola kakhulu nethe nezinye izithako.

Kuye kwafunyaniswa ukuba "Cefotaxime" (readings ezifakwe kumGaqo-sikhokelo esemthethweni iyeza elithile, ukuphelisa amathuba kuyo phambi ukopha) liveza kwinqanaba eliphezulu noko iyabophelela kwiiproteni plasma, lo gama ixesha legalelo microbicidal yahluka kwisithuba seeyure 11-12. Ukuba arhente eqala ukuguqulwa ngokulungelelana kusiwa emzimbeni, kuquka ithambo (ubuninzi xi kwakhona iqatshelwe myocardium kunye esinyini nenyongo).

Eyona nto iphambili yazo uleyisayo njengomqobo placental kwaye iba yinxalenye yale pericardium neencindi fluid. I-avareji isiqingatha-ubomi efakwa drip ukumnika ingadluli iyure enye kwizitofu intramuscular - omnye imizuzu elinamanci asibhozo. Nayiphi uhlale zokwanda zokufunda zingaphawulwa - inxalenye amacandelo kunye esiswini saso enyongweni, kunye nezinye (malunga 90%) - uchama. Kwimeko yokugqibela, umyinge metabolites esebenzayo kuphela kwi-20-30% ye idosi elawulwa, ngamanye malunga ne-70% yesisombululo mawungcwatywe umzimba ngaphandle usisisulu nokulungalungiswa zezakhiwo.

Ubungqina obubonakalayo buxela ukuba

Ezi arhente imiswe kakuhle nje blocker yeenkqubo ezasulelayo kunye ukudumba Cya, ingakumbi avelana cefotaxime abalekayo. Nobungqina oku izifundo lwezonyango nje kuphela - kwisigqibo esifanayo zingenziwa emva kokufunda izigxeko ezininzi ezilungileyo ziyaposwa kwi-website, umxholo leyo ichiza esebenzayo ukulwa kwamagciwane. Front isenzo amayeza beziyobisi ebanzi ngokwaneleyo, kodwa kaninzi "kwi emehlweni" ukuwa esinganyangekiyo okanye ukuphazamiseka zosulele sezintso khona womchamo, kwakunye nesifo eliphezulu zemiphunga.

Ndimele ndithi, nokuba ungubani ngokupheleleyo kwesi ukwakhiwa analog "Cefotaxime", nokuba "Tsefasin" okanye "Tsetaks" ayikwazi zabelwe ukusebenzisa kusekelwe phezu kweemeko ngentla. Inyaniso kukuba abantu abaninzi badla generics kuphela "ikopi izihlobo umfuziselo zengqo- yepateni yokuqala yokuziphatha, ngoko ke ikhadi amayeza ngqo ethathela ingqalelo ishedyuli kunye idosi" double "mazibale liyincutshe onamava.

Imveliso yokuqala kuyacetyiswa ukuba kusetyenziswe ukuba:

• umguli unesifo ngezifo yenkqubo nokuphefumla ngohlobo yinyumoniya, ithumba okanye iphika, kunye nezinye antibiotics musa kuwucima;
• isigulane umthwalo ngokuqhubekayo bacteria meningitis;
• iimvavanyo yaqinisekisa phambi endocarditis;
• kwixesha postoperative alikwazanga ukuphepha iingxaki ngohlobo wentshabalalo zizityalelo ulusu kunye / okanye inwebu amalungu ebalulekileyo;
• izifo kuhlala phantsi ithambo, kunye iinaliti intramuscular ngeziyobisi-izithethantonye angabi yempembelelo engafanelekanga phezu kwabo;
• negative-gram okanye gram-HIV amanxeba itshileyo elangena nosuleleko wavusa abasakhasayo (ukuya nokudumba);
• kukho imfuneko amanyathelo othintelo.

Iingcali ezizimeleyo badla ukukholelwa ukuba akukho nto ingako na analogu "Cefotaxime" nako ukubonisa kucaciswe imiba HIV kunye nesifo Lyme. Kubalulekile ukukhumbula sifanele eyayichaza yokuqala, phantsi isicelo rhoqo, umsebenzi ukumelana kakuhle (izimvo, azinikele bokuqonda kwekhosi unyango, izigulane ezibekwe iiforam).

Sebenzisa nokuba umthamo

"Cefotaxime" umyalelo (lwezitofu, ngokutsho kwezinye koogqirha kunye nezigulane azikho namandla njengokuba ucwangcisa dropper) ukuba kubekwe isenzo ebomini yokulwa izifo zintsholongwane uyakhetha kakhulu virus. Njengoko kukhankanyiwe ngaphambili, kukho iziphaluka ezintathu reagent kweenkonzo: yi uvuza iimela okanye jet, ngokunjalo nge ngenaliti intramuscular. imithetho yomanyano ukulungiselela kulwelo ukusebenza ayikho, ngoko kubalulekile ukujonga kwangaphambili indlela wolawulo beziyobisi.

Umenzi, ingakumbi, icebisa ngokulandela eli algorithm:

• ukuba kwizitofu / th: 1 gram powder ukuba kunyibilikele 4 ml yamanzi, lidocaine okanye novocaine;
• ngokuba Inaliti efakwa: 1 g wenkqu kuyimfuneko ukuba ukunyibilika emanzini engenazintsholongwane (ml 4);
• ngokuba / ku ukumnika: kwibhotile grams ezimbini cefotaxime kufuneka sidibanise 100 ml NaCl (0,9%), okanye enye ezintlanu ekhulwini iswekile.

Delivery time reagent:

• e / m iinaliti: 5-10;
• e / kwintshayelelo jet: 5.3 imiz;
• xa uzibekela dropper: 50-60 imiz.

Ukubalwa oyidlayo elungeleleneyo lomsebenzi ukwakhiwa reception kangangoko yenziwa ngabanye. Sithabathela ingqalelo ubudala yomguli kunye ubunzima umzimba wakhe, kwakunye uhlobo losulelo kunye nqanaba yophuhliso lwayo. Ukongeza, izilungiso ezenziwe kwi kwimbali ngamayeza nokunyanga.

Noko ke, imiyalelo kunjalo inika ingcaciso amazinga avareji yesicelo "cefotaxime" iziyobisi. Iinaliti (luthuli exutywe, ezichazwe iinkcukacha ngasentla, kodwa, Okubangel 'umdla kukuba, phantse bonke ingxelo esilawulwa ingcamango yokuba inaliti - inkqubo kakhulu ebuhlungu mnandi, nazo zonke izindululo umenzi), ngokukodwa, omiselwe kwiimeko ayinzima, ndihlekeze iiyure 4-12 kunye nedosi enye ye-1-2 grams. Okunzulu kunye subcritical ebalulekileyo ngeenkalo / intshayelelo (ngomlinganiselo 2 g zonke iiyure ezi-4, kodwa hayi ngaphezulu kwe-12 g / ngosuku).

Bezifo abakwisigaba yokhetho sikhokelwe ubunzima abatsha nomonde umzimba bebonke osabela nomzimba ( "umgangatho" - ukususela ezimbini ukuya kwisithandathu jet iinaliti; 50-180 mg / kg).

imiphumela emibi

Xa ukunika medicament "Cefotaxime" (iinaliti amanqaku azikho nje yomlomo ogudileyo njengoko uvuza iimela, ekubeni intshayelelo / m Idla ngokuba buhlungu; ngenxa yesi sizathu, njenge "kuphela" lidla ukuba procaine okanye lidocaine) ayikwazi ngaphandle amacandelo amanyathelo Nedlac kwinkqubo kunye namaziko yesigulana.

kuvunyelwe:

• "Iimpendulo 'komzimba ngohlobo ezinkulu-isikali urticaria, angioedema okanye candidiasis;
• iingxaki kwinqanaba le iphecana zesisu (uyagabha, isicaphucaphu, kunqabile - senyongo cholestatic);
• ukuphazamiseka egazini (ukuhla count zegazi, igazi hemolytic kunye m. p.).

imiphumo libanda

ukwanda kakhulu kwi imfuno imihla igcwele dysbiosis kunye Encephalopathy; nalo benikela ulusu esicaphukisayo.

Umsebenzi ophambili kukuqinisekisa ukuba yokumisa unikezelo reagent emzimbeni. amanyathelo ayimfuneko ukuze uzinzise kurhulumente iyabophelela kunye nokusetyenziswa kweemveliso desensitizing amayeza (kunye esweni ngugqirha).

Ngokutsho Izimo kumenzi

Ngokutsho ingcaciso enikwe kwingxelo esemthethweni, "cefotaxime" (izitofu abantwana, ngokuqhelekileyo emiselweyo emva kokuba kweenyanga 30 ubudala, ngaphambi kokubhenela kwi-I / ukumnika) kufuneka ingasetyenziswa:

• ngexesha lokukhulelwa;
• hypersensitivity izithako;
• nokuvula nokuvala ukopha;
• Ukuba iziqephu enterocolitis sele emelwe embalini.

imithi

Kwesi sikhokelo original igxininisa ukuba ezinye izisombululo phantsi kwazo naziphi iimeko ukuba abasayi kwenziwa kunye (ukusuka isixhobo ezonyango) kunye ngeendlela zintsholongwane "cefotaxime".

Iinaliti (ngokusebenzisa se drip ngokwemiqathango yentsebenziswano amayeza kunye amacandelo nezinye iziyobisi, akukho ezahlukeneyo ukusuka isitofu / m), ngokukodwa, kungabangela umonakalo nezintso, ukuba "ezihlanganisa" ekuthethwa ngazo apha ukulungiselela ukwenza nayiphi aminoglycoside okanye umchamo loop. Kwelinye icala, interlocks secretion tubular zinqanda ngamandla inkqubo Nhoza reactant elinikiweyo kudaleke nokwanda eyavela.

Ukudityaniswa kunye antiplatelet kwakhona engathandekiyo ngenxa ingozi ukopha.

imfundo ekhethekile

"Cefotaxime" (analogs tableted, ngokutsho ncomo kunye nezimvo ezisebenzayo ngaphantsi) ngamanye amaxesha Uxhokonxwa zobuxoki Kumbusa isampula "spoofs" uhlalutyo umchamo ukuba glucose lokwenyaniso.

ixesha elide unyango wekhadi icandelo ukwakhiwa egazini kufuneka lwenziwe nini phandle hayi ngaphantsi kwe-1 kwexesha ngeentsuku ezili-10.

Ngemihla okuqala onyango akukhethi i kakhulu lwe norhudo. Kwaye, Akumangalisi, analog enjalo "Cefotaxime" (kubantwana abangaphantsi kweminyaka eli-12 ekubhekiselelwe 'understudy "akunconywa), njengoko" Fagotsef "umfanekiso ofanayo yinto azixhaphakanga.

Ukusela utywala ngexesha unyango kwi ngokususela reagent akuvumelekanga ngokungqongqo.

Yeyiphi eyona kanye nelo ukuba "Cefotaxime" bacebisa ukusetyenziswa ziingcali ezizimeleyo?

Izimvo ku "Sefotake" yaye "Tsefantrale"-ntonye imveliso echazwe imithi, ogalelwe. Xa nokubuyekezwa, injongo yabo weprakthishina kaninzi ngaphezu ukubhala ngaphandle imiyalelo ngugqirha ukuba uthenge enye efanayo "Tsefabola" okanye "irhafu-on-BID." Noko ke, ezinye izigulane zidla ukukholelwa ukuba isiphumo kwezonyango le leesampuli ezichazwe ezichazwe kakubi kwaye amathuba okuba kuphuhliso reactions Nedlac ephezulu.

Xa iiforam lo mbuzo kuvuswa ukuze ahlabe 'cefotaxime' ukuba akazange buhlungu, oogqirha abaninzi ukucebisa:

• test, kwaye akukho mpendulo ingaba ukungaphatheki nto ezithile (ukuba lesi sifo zokunyanzelisa procaine exutywe yangumgubo, ngoko kukho isizathu sokukholelwa ukuba le nto - ngenxa yokuba nokwaliwa kunokuba neziphumo ngqo iziyobisi);
• khangela ukuba omnye endilisekileyo.

Uhlalutyo izimvo lubonisa ukuba uninzi "intlonelo" phakathi ntonye ezinikwe "I Lorax." Noko ke, ngaphambi ukutshintshwa reactant enye ukuya kwenye kusoloko kufuneka udibane yincutshe.