Guide amlodipine

Medicine "Amlodipine" mhlawumbi uyazi ukuba abaninzi lokuqala-ngesandla. Ngokusisiseko, eli chiza emiselweyo kwizigulana angina. Makhe sihlolisise ichiza "Amlodipine" ogama imiyalelo eziqulathe ulwazi ilandelayo.

Uqulunqo. Elinye icwecwe (5 mg) eziqulethwe iziyobisi amlodipine besylate esebenzayo. Njengoko excipients kusetyenziswa lactose, iitapile starch, collidone, microcrystalline kwincindi, wemagniziyam stearate.

inkcazo jikelele. "Amlodipine" Amacwecwe ezimhlophe okanye emhlophe phantse nge joint-kabini ezimbini. Ngamanye amaxesha ukukhanya inokuba kwentlenga langoku.

Pharmacodynamics. Dihydropyridine ithe - iibloko calcium "slow" yesibini-generation channels kuye gipotezivnoe kunye neziphumo antianginal. Ezinxulumene receptor dihydropyridine kwaye ithwala kuvalwe iindlela amajelo calcium, oku kunciphisa transmembrane indlela ion calcium kwi kwiseli (kangangoko omkhulu umsipha agudileyo emithanjeni kunokuba myocytes inhliziyo). ukusebenza Antianginal kubangelwa ukwandiswa kwemithambo kunye arterioles ibekwe kwimida: angina umenshaetsnizhaet ubuzaza ischemia engabalulekanga, Umthambo peripheral ayanda, nto leyo eye yanciphisa uxhathiso iyonke nemithambo peripheral, ukongeza inceda ukwehlisa ukulayisha entliziyweni, kunciphisa imfuno intliziyo oksijini. Xa izigulane angina, idosi enye yemihla ngemihla kwandisa ixesha baleka fiznagruzki, ukucola uphuhliso ischemia kunye angina, kunye yonke kunciphisa ubuninzi yokuhlaselwa angina kunye nemfuneko nitroglycerin. Ngenxa yoko, izigulane angina ufuna "Amlodipine" sikhokelo le ubungqina.

Pharmacokinetics. Emva ulawulo yomlomo ichiza ngcembe etsalwe iphecana zesisu. avareji bioavailability Absolute yi-64%, i-kanzulu kakhulu kwi serum igazi emva kweeyure 6-9. ukulingana ezinzileyo igazi kwenziwa umhla wesi-7. Ukutya awuchaphazeli ukufunxeka amlodipine. Kubantu abalupheleyo (kweminyaka engama-65) ukuba kukhuthaza ichiza kancinane xa kuthelekiswa abaselula, kodwa lo mahluko ayikho ngokwezonyango ephawulekayo.

"Amlodipine" umyalelo leyo iqulethe yonke inkcazelo efunekayo unalo zibonisa zilandelayo kwisicelo: i umfutho wegazi (indibanisela namanye okanye ezifanayo iindlela monotherapy), angina exertional, angina vasospastic (angina Prinzmetal ngayo).

Izimo.

- uvakalelo oluphezulu ukuya esisebenza kunye nezinye nezakhi dihydropyridine;

- hypotension ngohlobo kakhulu;

- mothuko cardiogenic, nciphisa;

- angina ezingazinzanga (ngaphandle - angina Prinzmetal);

- lokwaphusa nokukhulelwa;

- abantu abangaphantsi kweminyaka eli-18 ukhuseleko kunye nefuthe akukasekwa.

Oyidlayo kunye nendlela isicelo. Thatha "Amlodipine" umyalelo libonelela ngolu hlobo lulandelayo: ngaphakathi, idosi ubuncinane 5 mg, ubuninzi - 10 mg 1 ixesha ngosuku. Xa ithamo hypertension yesondlo ingaba 5 mg ngosuku. Xa imivimbo ethathwa kanye 5-10 mg ngosuku. izigulane Thin, kwakunye izigulane eliphantsi kunye nezigulane yesibindi kakuhle Kwendalo ilawulwa 2.5 mg.

imiyalelo ezizodwa. Ngexesha unyango with "Amlodipine" kufuneka balandele ubunzima kunye nokusetyenziswa kwezinto ezifana sodium, maxa wambi kufuna ukutya okhethekileyo. Kubalulekile ukulandela ucoceko yomlomo kunye amazinyo, ndwendwela ugqirha wamazinyo rhoqo (ukuthintela iintlungu kunye ukopha kweentsini). Ngokwandisa ithamo kwi abadala kufuna esweni ngenyameko. Isiphumo ichiza kwi uyakwazi ukuqhuba imoto akukho data. Nangona kunjalo, kufuneka kukhunjulwe ukuba abanye abantu kuyo kunokubangela nesiyezi omncinane kunye ukozela.