NSAIDs - oku ntoni iziyobisi? NSAIDs: yombhalo. Isizukulwana esitsha NSAIDs

Ufinyezo NSAIDs - ngaba ndingekuxeleli na malunga nantoni? Ukuba akunjalo, sicebisa ezimbalwa banzi zexa elizayo yam nifunde ukuba amele ezi oonobumba abane twisisaka. Funda inqaku - yaye yonke into aya kuba icace ngokupheleleyo. Sinethemba lokuba asinto nje ulwazi, kodwa fun!

NSAIDs - yombhalo

Asiyi kuba lide bazikhathaza kubafundi bethu ebumnyameni. NSAID imele non-steroidal amachiza anti-ukudumba - iziyobisi ngexesha lethu zithandwa kakhulu kwaye ethandwa, ukuba bayakwazi ngaxeshanye ukuphelisa intlungu nokunciphisa ukudumba kwizigqeba ngezigqeba umzimba ... Ukuba kude kube ngoku akuzange kwavela imfuneko unyango NSAID - oku kuthathelwa ingqalelo phantse nomnye ummangaliso. Wena - enye luckies ezinqabileyo, ngenene, impilo yakho nomona!

Silindele umbuzo olandelayo kwaye kwangoko usixelele utoliko elithi "non-steroidal". Oku kuthetha ukuba la machiza hormone, ie, It ayiqulathanga kubume yayo nayiphi iihomoni. Kwaye kulungile kunene, kuba sonke siyazi indlela kunokuba iihomoni engalindelekanga kwaye iyingozi.

Le NSAIDs kakhulu ethandwa

Ukuba ucinga ukuba NSAIDs - iyeza abamagama kunqabile wenza kubomi bemihla ngemihla, koko wena engalunganga. Abantu abaninzi musa naxa kangaphi kufuneka sisebenzise non-steroidal amachiza-ukudumba ukunyanga izifo ezahlukahlukeneyo ezihamba uluntu ukususela ukugxothwa Adam noEva kwiparadesi Kusch. Hlola uluhlu-mali ezinjalo, ngokuqinisekileyo ezinye zazo kwi yakho emithi ekhaya. Ngoko ke, ukuba NSAIDs ziquka iziyobisi ezifana:

• "Aspirin".
• "Amidopyrine".
• "Analgin".
• "Piroxicam".
• "Bystrumgel".
• "Diclofenac".
• "Ketoprofen".
• "Indomethacin".
• "Ketorol".
• "Naproxen".
• "Ketorolac".
• "Flurbiprofen".
• "Voltarengel".
• "Nimesil".
• "Diclofenac".
• "Ibuprofen".
• "Indopan".
• "Ipren".
• "Upsarin UPSA".
• "Ketanov".
• "Mesulid".
• "Movalis".
• "UDenise".
• "Nurofen".
• "Ortofen".
• "Thrombotic ACC".
• "Ultrafen".
• "Fastum".
• "Finalgel".

Ewe, ukuba zonke iziyobisi NSAID. Uluhlu kanti, nangona amakhulu, kodwa, kakade, kude epheleleyo. Kodwa nangoku kunika uluvo lokuba ezahlukeneyo non-steroidal amachiza-ukudumba mihla.

A bit of amanqaku ngembali

Amachiza zokuqala abangekaphuhli NSAID ziye zaziwa kubantu ukususela kumaxesha amandulo. Hi xikombiso, ku eYiputa yamandulo, ukuba balahle yobushushu kunye ubuhlungu ngokubanzi willow ixolo - umthombo lendalo salicylates kunye omnye non-steroidal amachiza yokuqala anti-ukudumba. Ke kaloku ngaloo mihla oogqirha ngayo izigulane zabo bathwaxwa ayengi edibeneyo nangecesina, decoction of intwana yamafutha aqholiweyo yommirtile yeelamuni - ke nayo salicylic acid.

Phakathi kwiminyaka yee-19 leminyaka baqala ukuphuhlisa chemistry, leyo umfutho kuphuhliso Pharmacology. Ke izifundo ziye zaqhutywa Ukuqamba yokuqala iziyobisi evela izinto nemifuno ekrwada. kwisalicin Net ukusuka willow ixolo ukuba kuhlelwe ngo-1828 - yaba linyathelo lokuqala ekudaleni idlozi kuthi sonke "aspirin".

Kodwa kuya kuba baninzi ngakumbi iminyaka yophando phambi ichiza uya kuzalwa. umcimbi Grand kwenzeka ngo-1899. Koogqirha kunye nezigulane zazo ngokukhawuleza kakhulu iingenelo ichiza elitsha. Ngowe-1925, xa eYurophu isiqaqa bhubhane eyoyikekayo komkhuhlane, "aspirin" waba njengomsindisi ukuba baninzi. Ngowe-1950, i-non-steroidal nechiza elichasene-ukudumba waba Guinness Book of Records njengoko ndindisholo kunye nomthamo inkulu yentengiso. Kulungile, ngoko ke oosokhemisti zadalwa kunye namanye amachiza nonsteroidal anti-ukudumba (NSAIDs).

Ziziphi izifo anti-ukudumba amachiza ezingezo-steroidal zisetyenziswa

Uluhlu lwe Isicelo NSAIDs ebanzi kakhulu. Bayaphumelela kakhulu ukonakaliswa zombini izifo ezihlasela zosulele kwaye ezondeleyo ekhatshwa iintlungu kunye nokudumba. Ezi imihla kubantu lokufundisisa zophando ukusebenza kula machiza kweli unyango lwezifo sentliziyo yegazi. Yaye isibakala sokuba babe ingasetyenziswa xa uqaqanjelwa yomqolo, eyaziwa namhlanje phantse bonke (NSAIDs osteochondrosis Usindiso wokwenene).

Nalu uluhlu lwe iimeko sifo, xa kuthe ubonisa ukusetyenziswa NSAIDs ezahlukeneyo:

• Fever.
• Intloko, uqaqanjelwa.
• yokulunywa kwezintso.
• isifo samathambo.
• Igawuthi.
• Arthrosis.
• Ukudleka.
• SeTrojan.
• arthropathies ukudumba (samathambo psoriatic, ankylosing spondylitis, Reiter kaThixo syndrome).
• syndrome ubuhlungu Postoperative.
• Iintlungu syndrome babanama umothuko eliphakathi kunye notshintsho eyahlukeneyo arhabaxa.

Ulwahlulo lwe NSAIDs ngokwendlela isakhiwo yemizimba yethu

Ngokufunda eli nqaku, sele sibonile ukuba amachiza non-steroidal anti-ukudumba baninzi. Ukuba uzulazule phakathi kwabo kwi kancinane engcono ubuncinane, makhe sifumane kuhlelwe ezi mpahla. Kuqala kwinto zonke, ukuba kwahlulwa ngolu hlobo lulandelayo: Group - iqela acid kunye NSAIDs - nezakhi non-asidi.

I yangaphambili ziquka:

- salicylates (nako ukukhumbula i "aspirin").

- yezabelo acid phenylacetic ( "Aceclofenac," "Diclofenac" et al.).

- pyrazolidine (metamizole isodiyam yaziwa uninzi lwethu njengoko "Analgin" "phenylbutazone, njalo njalo).

- oxicams ( "tenoxicam," "Meloxicam", "piroxicam" "tenoxicam").

- yezabelo ze acetic acid indole ( "Sulindac", "Indomethacin", njalo njalo).

- uvumelane acid propionic ( "ibuprofen", njl ...).

Iqela lesibini - oku:

- sulfonamide uvumelane ( "Celecoxib", "Nimesulide", "Rofecoxib").

- alkanones ( "nabumetone").

Ukuhlelwa non-steroidal amachiza-ukudumba ukuba impumelelo yabo

Ukusetyenziswa NSAIDs xa ukuphatha osteochondrosis kunye nezinye izifo ezidibeneyo ekwaziyo ukusebenza ngokoqobo ebalulekileyo. Kodwa ke, ngelishwa, hayi onke amachiza bayalingana impumelelo yabo. iinkokeli Absolute kubhekwe phakathi kwabo:

• "Diclofenac".
• "Ketoprofen".
• "Indomethacin".
• "Flurbiprofen".
• "Ibuprofen" kunye namanye amachiza.

Amachiza idweliswe ukuze kuchazwe isiseko; t. e. esekelwe phezu kwazo zingaphuhliswa uze kungena NSAIDs ezintsha womnatha ekhemesti, kodwa ngaphantsi igama elahlukileyo, waliguqula ngokufuthi amaxabiso aphezulu. Ukuze ukuba bangachithi imali wakho ngelize, bafunda njani ukuba kwisahluko esilandelayo. Ulwazi oluqulethwe kuyo, kuya kukunceda ukuba ube ephosakeleyo kunye ukhetho.

Yintoni ukufuna xa ukhetha amayeza

NSAIDs - oku, kuba becala, iziyobisi kakhulu mihla, kodwa, eza ekhemesti, kungcono ukuba wazi kwezinye bokuqonda ukuba. Ntoni? Kodwa ukufunda!

Umzekelo, ukhetho kukuba kubhetele ukuthenga i "diclofenac", "Ortofen" okanye "Voltaren". Kwaye uzama ndikubuze ayinikiwe, yeyiphi kwezi machiza kungcono. Kungenzeka, uza kucetyiswa enye into ibiza kakhulu. Kodwa ke into yokuba ukwakhiwa mithi phantse twatse. A umahluko amagama kuba iveliswayo mveliso ezahlukeneyo, zooyise kunye iimpawu zahlukile enye kwenye. Kunjalo ke, umzekelo, "indomethacin" yaye "indomethacin" okanye "ibuprofen" yaye "Brufene" njalo-njalo. D.

Ukuze siqonde isiphithiphithi, qho kufuneka ujonge ngocoselelo xa ujonga isingxobo, ngokuba apho kufuneka banikwe izinto eziphambili iziyobisi esebenzayo. ezibhaliweyo Kuphela, oko kuya kusenza oonobumba abancinane.

Kodwa loo nto bonke. Enyanisweni, akukho lula kangaka! NSAID-analogu of imithi esiqhelekileyo ukuze ngesiquphe ingadala komzimba basabela okanye imiphumela ukuba zange ngaphambili ulandelwe. Yintoni ingxaki? Isizathu unakho kulala ongeziweyo ezongezelelweyo, leyo, Kakade ke, le nto kwiipakethe kubhaliweyo. Ngoko ke, simele sifunde ngakumbi lo myalelo.

Esinye isizathu esinokuba ukuba iziphumo ezahlukeneyo zamachiza analog - umahluko balawule. izityhakala badla musani ihlawule ingqalelo kuyo, kodwa ndabulaleka. Ngapha koko, encinane ubukhulu tabletochki isenokuba "ihashe" idosi enye into esebenzayo. Kwelinye icala, iipilisi okanye njengezingxobo enkulu kwenzeka iqulunqwe fillers nge-90 ekhulwini.

Ngamanye amaxesha le arhente zikwafumaneka kwi ifomu retardirovannoy, t. E. Njengoko amayeza eyandisiweyo isenzo (elide). Into ebalulekileyo iziyobisi ezifana na ubuchule ekufuneka ngokuthe wendele, ukuze isiphumo yabo kuhlala imini yonke. Loo kulungiselelwa akuyomfuneko ukuba asele amaxesha 3 okanye 4 ngemini, ngokwaneleyo ukuba idosi enye. Olu phawu we ichiza kufuneka ziboniswe kwi isingxobo okanye isihloko. Umzekelo, "Voltaren" kwifomu kade ebizwa ngokuba "kunamandla Voltaren."

Uluhlu analogue iziyobisi eyaziwa

Thina ushicilele iphepha encinane ukukopela ngethemba lokuba oko kuya kukunceda ngcono indlela iiphakheji ezininzi kwikhemesti ezintle. Masithi ngoko nangoko kufuna NSAIDs ngempumelelo osteoarthritis kuphele iintlungu ndityiwa. Wakhupha iphepha ukukopela uze ufunde uluhlu kulandelayo:

- analog "Diclofenac", ngaphandle i "Voltaren" sele sitshilo yaye "ortofen" nazo "Diklofen", "Dikloran", "Diklonak", "Rapten", "Diklobene", "Artrozan", "Naklofen".

- "Indomethacin" wathengisa phantsi yemiyinge ezifana "Indomin", "Indotard", "indomethacin", "Revmatin", "Indobene", "Inteban".

- analogue "Feldene" "Erazon", "pyroxene", "Roksik", "pyroxene".

- analogue "Ketoprofen", "Flexi", "Profenid", "Ketonal", "Artrozilen", "Knavon".

- A ethandwa bangasukela "ibuprofen" ifumaneka njengenxalenye iziyobisi ezifana "Nurofen", "Reumafen" "Brufen", "Bolinet".

imithetho NSAID

NSAIDs esinxulunyaniswa kunye nenani ziziphumo ebezingalindelekanga, ngoko ke kucetyiswa xa ilawulwa ukuba bagcine nemithetho zilandelayo:

1. Funda le miyalelo ze ulandele iingcebiso ukuba iqulethe - ezifunekayo!

2. njengezingxobo Xa kubhalwa okanye iipilisi uthathe kubo iglasi yamanzi - oku kuya kukhusela isisu sakho. Lo mgaqo kufuneka ilandelwe nokuba xa usele amachiza mihla (olinani ubone ezikhuselekileyo) ngenxa yokuba silumke engaphezulu ayisoze;

3. Musa kulala phantsi emva kokuba uthathe amayeza malunga sisiqingatha seyure. Inyaniso yokuba amandla womxhuzulane kuya kuba negalelo sicatshulwa kakuhle philisi phantsi umphimbo;

4. Ukususela iziselo ezinxilisayo kufuneka kushiywa, njengoko babedityaniswa NSAIDs notywala - umxube oyingozi ezinokubangela izifo ezahlukeneyo isisu.

5. Ngenye imini, kufuneka uthathe ezimbini iziyobisi ezahlukeneyo non-steroidal - akuyi kwandisa iziphumo ezidibanisayo, kodwa kunokuba lushwankathela iziphumo ebezingalindelekanga.

6. Ukuba iyeza swi nga pfuna, qhagamshelana nogqirha wakho, mhlawumbi nawe igcuntswana leyeza kakhulu elinikwe intsingiselo.

side effects kanye gastropathy non-steroidal

Ngoku uya kufumanisa ukuba yintoni na gastropathy NSAID. Ngelishwa, zonke NSAIDs ukubonisa iziphumo ebezingalindelekanga omkhulu. Bathi ukusebenza ingakumbi elibi iphecana zesisu. Izigulane uphazamise kubonakaliswa ezifana

• Isicaphucaphu (ngamanye amaxesha womelele kakhulu).
• Heartburn.
• Ukubuyisa.
• Ukuqunjelwa.
• Ukopha emathunjini.
• Norhudo.
• isilonda Duodenal wesisu.

Yonke le nkathazo ngasentla NSAID gastropathy. Ngenxa yoko, oogqirha rhoqo amisele izigulane zabo ukuzama ithamo lisezantsi kangangoko of non-steroidal amachiza odidi anti-ukudumba. Ukunciphisa iziphumo eziyingozi kwi isisu kunye namathumbu, kucetyiswa ukuba soze ukuthatha la machiza ungatyanga, uze wenze oko kuphela emva kwesidlo enzima.

Kodwa iingxaki izitho zokugaya - ukuba asingabo bonke side effects bayakwazi ukuvelisa ezinye NSAIDs. iziyobisi ezithile kakubi kuchaphazela intliziyo kunye nezintso. Ngamanye amaxesha ukuthatha wabo zikhatshwe intloko ebuhlungu kunye nesiyezi. Enye ingxaki enkulu - kuba nefuthe esiphanzisayo intra-articular intlala (Kakade ke, ukusetyenziswa ixesha elide kuphela). sizukulwana Ngethamsanqa, kufumaneka ngokorhwebo entsha NSAIDs, apho ubukhulu becala ayichatshazelwa kwezi kuneengxaki.

Nonsteroidal amachiza anti-yokukrala isizukulwana esitsha

Kule minyaka ingamashumi amabini idlulileyo, iinkampani ezininzi zamachiza kakhulu ekuphuhliseni NSAIDs ezintsha mihla, apho, kunye nolawulo olusebenzayo lwe iintlungu kunye nokudumba, kuya kuba neziphumo ebezingalindelekanga kangangoko kunokwenzeka. imizamo usokhemisi zaye isithsaba ngempumelelo - iqela lonke kwisizukulwana esitsha iziyobisi sele iphuhlisiwe, ebizwa uyakhetha.

Khawube nomfanekiso - la machiza phantsi kweliso elibukhali likagqirha nga nisele iikhosi elide kakhulu. Kwaye ixesha ayinakulinganiswa kuphela iiveki neenyanga kunye neminyaka. Amayeza kweli qela musani kunokuba yingozi kwi intlala articular, imiphumela emibi kakhulu kangako yaye kunika ngokubonakalayo musani kubangele iingxaki.

isizukulwana esitsha NSAIDs - nto iziyobisi ezifana:

• "Movalis".
• "UDenise" (aka - "nimulid").
• "Arcoxia."
• "Celebrex".

Ezinye iinzuzo siza kucacisa umzekelo 'Movalis ". Ifumaneka njenge icwecwe eqhelekileyo (7.5 mg ne-15) kunye suppositories-15 mg, kwaye ampules zeglasi yolawulo intramuscular (15 mg). Isebenza iyeza ithambe kakhulu, kodwa kwangaxeshanye kakuhle kakhulu: imini yonke kwanele tablet nje omnye. Xa izigulane yabonisa unyango ixesha elide samathambo kasikrobana okanye amadolo amalunga, "Movalis" nje ezinye endaweni yazo.

iintlobo ezahlukeneyo NSAIDs ziyafumaneka

Uninzi amachiza ethandwayo nonsteroidal anti-ukudumba zingathengwa kwaye kusetyenziselwa kuphela ngokohlobo iipilisi kunye njengezingxobo ngenxa nolawulo ngomlomo, kodwa namafutha aqholiweyo, ijel, amakhandlela kunye nezisombululo ukuze ngenaliti. Kwaye ngokuqinisekileyo elungileyo kakhulu, ngenxa yokuba kule yantlukwano yenza kube lula kwezinye iimeko ukuthintela umonakalo ngexesha unyango kunye nemveliso ngaxeshanye ngaphezulu isiphumo ngokukhawuleza nezinyangayo.

Ngoko ke, isizukulwana esitsha NSAIDs e osteoarthritis esetyenziswa ngenaliti, impembelelo ngaphantsi kakhulu kwi gastro-emathunjini phecana. Kodwa kukho icala Flip kule ingqekembe: xa kulawulwa intramuscularly, phantse zonke iziyobisi non-steroidal unako ukuvelisa ezinobuzaza - necrosis yethishyu kwezihlunu. Kungenxa yoko le nto NSAIDs inaliti zange lakwenza ixesha elide.

Ngokubanzi, iinaliti amiswe i exacerbation lwezifo ukudumba kwaye sisiba mandundu namalungu yomqolo, ekhatshwa kakhulu nodandatheko. Emva kokuba imeko yesigulane kuphucula, kuba kunokwenzeka ukuba bayeke ukuba iipilisi kunye neendlela zangaphandle ngohlobo namafutha aqholiweyo.

oogqirha ngokuqhelekileyo bahlanganise iifom umthamo ezahlukeneyo, isigqibo ntoni yaye unokubangela xa inzuzo enkulu kumguli. Esi sigqibo icacile: Ukuba awufuni ukuba ndihlelwe ngokwabo self-unyango izifo eziqhelekileyo ezifana iintlungu ophantsi umva okanye osteoarthritis, cela uncedo kwiziko lonyango, apho wena uya kukwazi ukunceda.

Ndingasebenzisa NSAIDs ngexesha lokukhulelwa

Oogqirha Sazisa ngamandla uthatha NSAIDs kumabhinqa akhulelweyo (ingakumbi yokuvalwa kuba ezintathu wesithathu), kunye nabondli abo ukuncanca. Bakholelwa ukuba eli qela machiza kuchaphazela kakubi i kokumitha mbungu kwaye kumenze malformations ezahlukeneyo.

Ngokutsho kweminye imithombo, nto iyeza ongenabubi, ingqalelo ngabaninzi njenge "aspirin", uyakwazi kwandisa ingozi yokuba isisu ekukhulelweni ekuqaleni. Kodwa ngamanye amaxesha noogqirha izinto ezibonisa ezimiselweyo abafazi iziyobisi olusebenzayo (ezinyiniweyo rate kunye ngeedosi engephi). Kwimeko ethile nganye, isigqibo kufuneka senziwe ugqirha.

Xa bekhulelwe, abasetyhini basoloko ingxaki emva kwaye kukho imfuneko ukusombulula le ngxaki usebenzisa iziyobisi nonsteroidal antiinflammatory njenge kakuhle kakhulu kwaye ngokukhawuleza. Kulo mzekelo, wavumela ukusetyenziswa "Voltaren Gel." Kodwa - kwakhona - elizimeleyo ukusetyenziswa kwalo kunokwenzeka kuphela ezintathu yokuqala neyesibini, ekukhulelweni kamva ukusetyenziswa kweli chiza enamandla kuvunyelwe kuphela phantsi kweliso kagqirha.

isiphelo

sanixelela ukuba yintoni abayaziyo malunga ngokwabo NSAIDs. Ziqonde izifinyezo, nokubekwa ngeemveliso zamachiza, imithetho ukwamkela zabo, ulwazi malunga neziphumo ebezingalindelekanga - iluncedo ebomini. Kodwa sifuna ukubona imfuneko amayeza yavela ezivela kubafundi bethu kancinci kangangoko kunokwenzeka. Ngoko ke, xa ukuhlukana sinqwenela ukuba impilo enamandla ezilungileyo!