Imiyalelo yokusebenzisa "Azimeda" malunga ncomo ichiza

Abantu abaninzi bazama ukuphepha unyango zintsholongwane ngenxa yeziphumo ebezingalindelekanga eli qela iziyobisi. Nangona kunjalo, kukho machiza ukuba kuthiwe kuphephe - it macrolides. Aba nempembelelo embi lincinane kakhulu emzimbeni kwaye bayakwazi ukuphelisa kwamagciwane ngokukhawuleza. "Azimed" - enye nabammeli bezi antibiotics. Yonke ingcaciso eyimfuneko malunga nokwamkelwa kunye nonyango iimpawu medicament iqulethe imiyalelo ukusetyenziswa. "Azimed" livela ngeendlela ezininzi, oko asetyenziselwa ukunyanga izigulana onke amaqela ubudala.

inkcazo ngokubanzi indlela

Udidi imithi macrolide, wongezelela lithetha "Azimed". Eli chiza mihla antibacterial, esenziwa inani iinkampani zoxubo - "Kyivmedpreparat" yaye "Arterium" (Ukraine). Xa kuthelekiswa erythromycin, kuthetha uzinze kwindawo asidi ye phecana wokudla, ebonelela ngayo bioavailability mkhulu kakhulu kucutha umngcipheko yeziphumo ebezingalindelekanga.

"Azimed" ungena nzulu ancedisana amalungu, apho waqalisa yande. Le ndlela yenza ichiza lipophilic kakhulu. iziyobisi High ingqalelo kokuqhambuka kwesi sifo kulwa iiyure 36-50. Oku kwenza kube lula ukuba ukunciphisa idosi yemihla ngemihla kunye nomthamo rhoqo amayeza, nto leyo nayo inzuzo ebalulekileyo. I-zintsholongwane enoluhlu olubanzi iziqhamo, njengoko echazwe imiyalelo ukusetyenziswa. "Azimed" wathabatha ulingo lwezonyango kuyimfuneko apho ukusebenza kunye nokhuseleko ichiza singqiniwe.

Yintoni na izithako?

Isenzo elwa beziyobisi inika into esebenzayo esisiseko - Azithromycin. Le azalide ukuba umsesane lactone 15-membered nge i-atom nitrogen olungaphezulu ngumongo. Ukwakheka chemical kunye nesakhiwo kwemolekyuli kukhupho azithromycin phakathi amanye amalungu macrolides. Avuleke into umsebenzi omkhulu ulele gram-HIV: enflyuentsy coli (Afanasyeva, Pfeiffer), catarrhalis Moraxella, chlamydia trachomatis, Mycoplasma inyumoniya.

Ubuntununtunu bokuba azithromycin umboniso pertussis kunye isifo somqala omhlophe, Helicobacter pylori, ureplazmu, spirochetes, anaerobes Listeria. Eziphilayo ukumelana erythromycin, hayi olubuthathaka kakhulu kwi "Azimedu".

Awongeziweyo amaqela ifakiwe umchiza ukwakhiwa ichiza, nokukhuthaza ifuthe therapeutic. Ezi ziquka calcium anhydrous hydrogenphosphate, nemagnesium stearate, umbona starch, microcrystalline kwincindi, titanium dioxide, lactose, macrogol, triacetin, hypromellose, sodium lauryl sulfate.

iintlobo macrolides

antibiotics Modern, macrolides zahlulwe zibe yendalo semisynthetic. Iqela lokuqala luquka erythromycin, leucomycin, oleandomycin, dzhozamitsi, spiramycin. Bona ezifunyenwe iintsholongwane ezithile. macrolides Natural luphawulwa kahle eliphezulu, kodwa le arhente yayintsholongwane eyosulela ngokwaneleyo ngokukhawuleza ukumelana kubo.

macrolides semi-eyenziwayo iqela elitsha arhente antibacterial. Zinelungelo uluhlu olubanzi yeziphumo, umsebenzi omkhulu elwa, ukuba ukunyamezeleka kakuhle umzimba. Isiphumo therapeutic abangathathi eso egcinelwe ixesha elide. Olu hlobo luquka azithromycin, clarithromycin, rokitamycin, fluritromitsin, roxithromycin. Uphawu lisahlulayo uyakwazi okuphembelela iintsholongwane gram-negative.

indlela isenzo

Macrolide "Azimed" abonakalisa isenzo elwa ngokuba nomthelela iiseli ribosome ngeentsholongwane kwaye ukuphazamisana protein yokuqaphela. arhente ezisulelayo abakwazi ukumelana kuhlaselwa kwaye ukubola. Eyona lisahlulayo a anti-ezithintela ukosuleleka kunye immunomodulating inyathelo wobulali, obonisa olwa nawo. Ngokungafaniyo nezinye nemithi, "Azimed" lingahlala iintsuku eziliqela.

kunikezelo

Ichiza ifumaneka ifom philisi (250 mg), amacwecwe (500 mg) kunye nomgubo kukunqunyanyiswa (250 mg of kweziyobisi asebenzayo). ifomu Pelletized yenzelwe kunyango abadala kunye nabantwana abanobunzima ubuncinane 25 kg. Ilungiswe ukusuka oluludaka lomgubo unalo elinuka incasa nobumnandi. Umthamo we igutyana - 20 okanye 30 ml. Kukwafakwe apha ngecephe yokulinganisa kunye isirinji.

Ubungqina obubonakalayo buxela ukuba ukusetyenziswa

Macrolide zintsholongwane "Azimed" lisetyenziswa ukunyanga ezahlukeneyo iimeko zophendlo lwezifo ze umyalezo esosulelayo. Ichiza kudla emiselweyo ukuba izigulane zobandlululo ukuya penicillins kunye cephalosporins. Phambi sisifo esibangelwa amagciwane uvakalelo azithromycin, omnye abanezakhono uya kuhlawula scheme data unyango medicament ngamnye.

Ubungqina obubonakalayo buxela ukuba "Azimeda" njongo zezi zifo zilandelayo:

• usulelo phecana zangentla ezihlasela zosulele ngokuphefumla (otitis, tonsils, pharyngitis, sinusitis, sinusitis);
• usulelo lwe phecana ukungaphefumli (ezifunyenwe yoluntu-pneumonia, iphika, exacerbation kwezifo ezingapheliyo);
• isifo somqala omhlophe, unkonkonko;
• izifo, ezosulela ngokwabelana ngesondo (gonorrhoea, i-chlamydia, chancroid, negcushuwa)
• urethritis, cervicitis;
• izifo ngomlomo (periodontitis, periostitis);
• iinkqubo ezosulelayo kwizihlunu ezithambileyo kunye nesikhumba (impetigo, migrans erythema esinganyangekiyo, pyoderma zasesekondari, beshiha, amaqhakuva kakhulu);
• isilonda esiswini okanye isilonda duodenal okubangelwa Helicobacter pylori.

Eli chiza ukuze anikwe njenge prophylaxis of unkonkonko ngemva kunye nomntu owosulelekileyo. Amachiza asetyenziswa sokuphuculwa abathwali zosulelo meningococcal. Azithromycin isetyenziswa woogqirha bamazinyo kuthintelo yophuhliso endocarditis.

Ityumbe ukuba "Azimed 'abantwana?

Kwiimeko ezingabantwana zesifo nokuphefumla umyalezo esosulelayo zezona common kakhulu. Xa abantwana izifo ezinjalo zingabangela uphuhliso iingxaki ezinzulu. Ukuze uphephe iziphumo ezingafunekiyo, oogqirha amisele antibiotics. iingcali ezininzi zikhetha ukusebenzisa kuba unyango lwe macrolides, ezifana "Azimed" (ukunqunyanyiswa okanye tablets).

Eli chiza liye Libonakala olusebenzayo ngokuphathelele zombini Iintsholongwane extracellular kunye intracellular. Wamiselwa an unyango lokuqala, nkqu kunye nezifo entsonkothileyo umyalezo yebhaktiriya. Le anti-amagciwane ikhuselekileyo, apho phantse akukho iziphumo ebezingalindelekanga kwaye ngoyaba kakuhle umzimba. Ngokuqhelekileyo, abo emiselweyo kids abanezakhono ithamo ubuncinane "Azimed" (100) beziyobisi. Ngokuba abantwana, le ndzo ukwimo esebenzayo uthathwa ekhuselekileyo. Oku kuthetha ukuba 5 ml lokunqunyanyiswa ogqityiweyo iqulethe 100 mg azithromycin.

Indlela yokulungisa ukunqunyanyiswa?

Kubalulekile ukulandela imithetho ukusebenzisa iziyobisi. Kulo kuxhomekeke ngqo kwi ukusebenza kwayo ngamayeza nokunyanga. Indlela ukuzalela "Azimed" ukufumana ukunqunyanyiswa? Lomgubo kwi igutyana apho medicament kukuba kuphekwe. Ukuze benze oku, ukuba isirinji yokulinganisa ngaphandle 11 ml yamanzi zipholile semzini kongezelelwa igutyana. Emva koko, lo mxube iziphumo kufuneka kuzanyazanyiswa ngocoselelo ukuze ifikelele kubunzima eyohlobo olulodwa. Ngenxa yoko ke umele uvule 25 ml lokunqunyanyiswa kwalo.

Le mveliso ogqityiweyo ligcinwa iintsuku ezi-5 kuphela, emva koko lalisetyenziswa akuvumelekanga ngokungqongqo. Phambi isitsha ngalinye ithamo kufuneka kuzanyazanyiswa. Umlinganiselo imali eyimfuneko amayeza ngumntu isirinji okanye ngecephe. Emva kokufumana i "Azimeda" kufuneka asele isixa elincinane ulwelo (iti, juice) ukucoca kwisisu ngomlomo ukusuka oluludaka eseleyo. Naan okanye isirinji emva ukusetyenziswa kufuneka ahlambe emanzini aphilileyo kwaye zonekwe.

balawule

Umthamo ofunekayo ichiza ugqirha ubala ngabanye. Ngokutsho imiyalelo, ezimbi ezosulelayo Kwiphecana eliphezulu kwaye ukungaphefumli Kucetyiswa ukuba unike i-10 mg esisebenza kwekilogram ubunzima isiguli ngasinye. Oko kukuthi, umzekelo, umntwana onobunzima 5 kg kufuneka anikwe 2.5 ml nokunqunyanyiswa.

Xa uhlobo iipilisi (250 mg) of ichiza eboniswe abantwana abanobunzima ngaphezu kwama-25 kg. Ezinye iingcali bacebisa enika ichiza ngokohlobo ukunqunyanyiswa, ukuba umntwana ubunzima ngaphantsi kwama-45 kg. Kule meko kungenzeka ukuba abe olungumgubo yomlomo zokumiswa "Azimed" 200 mg (lokunyusa ivolyum 30 ml). Ukuba ubunzima somntwana ngaphezulu kwama-45 kg idosi emiselweyo abadala. Irejimeni yonyango olukhethiweyo kwi kwingqiqo ingcali.

Ubuninzi reception idosi yemihla ngemihla iya kuxhomekeka Uxilongo kunye ukubakhona kwezifo ezihamba. izigulane abadala baye banikwa "Azimed" 500 mg. Le oyidlayo kudla ethathwa kanye ngemini. Noko ke ezimbi, izifo ezidluliselwa ngeentlobano zesini, migrans erythema kunye isilonda ezingapheliyo kubefundisi Helicobacter pylori luboniswe ukuba 1 g azithromycin ngexesha elinye ngosuku.

kufuneka ndiyeke Xa ekuthatheni ichiza?

Iyeza contraindicated xa ukunganyamezelani, hypersensitivity ukuya macrolides okanye udweliso ekwakhiweni. Ukwamkela ichiza kunokubangela iingxaki ezinzulu. Kwakhona, "Azimed" ngokohlobo iipilisi hayi emiselweyo izithuba kubantwana ubunzima ngaphantsi kwama-25 kg kwaye kwabasetyhini ngexesha lokukhulelwa.

nto Active umzimba esibindini kwaye kwazona kwi enyongweni. Ngenxa yoko izigulane kunye imbali ngaye kukho yanyhashwa kwesibindi, ayikhuthazwa tu into yokuba ukusebenzisa nemithi esekelwe azithromycin. Phambi ngobulali utshintsho kwekhono sezintso ke umthamo iyeza ayikho imfuneko yoko, kodwa unyango izigulane kufuneka abe phantsi kweliso labezempilo. Ngokukhathalela ukumisela amayeza izigulane abalupheleyo.

Yintoni iziphumo ebezingalindelekanga kunokubangela 'Azimed "?

Zintsholongwane kwiimeko ezininzi ukunyamezeleka kakuhle. Isizathu siyifumana yokuba macrolides azikho ziyityhefu kwaye ikhuselekileyo phakathi imithi elwa. Oku kungqinwe angqina nomonde, kunye nemiyalelo yokusebenzisa. "Azimed" kunqabile kuphakamisa uphuhliso iziganeko ezibi ukuba ngokufuthi oluvakaliswe lokugaya. Norhudo, ubucaphucaphu, ukugabha, flatulence, iintlungu esiswini - ezi ezinye iimpawu ezininzi eziqhelekileyo iziphumo ezibi beziyobisi emzimbeni.

Ulawulo Chronic-arhente antibacterial basenokuba i uxabane ngokohlobo wentlonze yabangxamayo, izigxala, ukurhawuzelela. nemiphumela emibi kakhulu - Stevens-Johnson syndrome, ityhefu epidermal necrolysis - zinqabile kakhulu.

Ukususela icala iziphumo ebezingalindelekanga wokuva (iithowuni okanye ingxolo ezindlebeni, bakuva ilahleko) ingathityazwa yaye zenzeka manqaphanqapha. Inkqubo luvo nabo ukuphendula elingalunganga kuthomalaliso isibulala-zintsholongwane. Oku kuzibonakalisa iimpawu ezifana nesiyezi, incasa enxamnye, unditsho, somnolence, asthenia, ugwayi.

iziganeko Ezingalunganga Kwakhona ithetha senyongo cholestatic, necrotizing hepatitis, ukothuka anaphylactic, lwegazi, ukuba ndlongondlongo, ixhala, thrombocytopenia. Ukurhoxiswa okanye "Azimed" macwecwe bayeke ukusebenzisa uphuhliso yeziphumo ebezingalindelekanga.

Iimpawu ze isicelo

Olwa nawo kufuneka zidityaniswe kakuhle nokusetyenziswa namanye amachiza ezinokuthanani bioavailability kunye nokusebenza. unyango ngaxeshanye kunye asidi bazakucotha inkqubo kukufakwa ichiza, yintoni na endithintelayo imiyalelo isigulane ukuba ukusetyenziswa. "Azimed" kufuneka kuthathwe kwiiyure ubuncinane ezimbini emva esesiwini.

Macrolide ekwaziyo ukunyusa serum lwee- anticoagulants, valproic acid, cyclosporin, theophylline, yiergot amalungiselelo. digoxin zintsholongwane kungandisa bioavailability ngomlomo.

Ukuthintela imiphumela engamkelekanga unyango zintsholongwane kuyimfuneko ukulandela ngokungqongqo iingcebiso kagqirha, ukuthobela idosi irejimeni, kungekhona ukuze kwandiswe umthamo. Kubalulekile ukuba kuphoswa ngelixa ezithatha ichiza. Ngeedosi ezinkulu, "Azimed" (500 mg) ingasetyenziswa ukunyanga abantu abadala kuphela.

isiyobisi Antibacterial kucetyiswa athathwe iyure enye phambi kokuba izidlo okanye iiyure ezimbini emva kwesidlo. Tablets kwehle imali njengomvumbi yamanzi, kunye nokunqunyanyiswa. Umntwana uvumelekile ukuba kunyanga isiselo (ukunqunyanyiswa) isiselo okanye iti. Xa zambethe loo "Azimed" ligcinwa akukho iintsuku ezingaphezu kwe-5 efrijini. Emva kokuba ithamo yokugqibela kufuneka lokubhangisa zeentsalela oluludaka igutyana.

Yintoni indawo 'Azimed "?

Ixabiso iziyobisi na iindleko eziphezulu ephezulwana kwezinye izinto antibacterial. A ukulungiselela ngohlobo iipilisi kunye 500 mg idosi kwi isigulana kuxabisa 160-200 engange. Iindleko zokumiswa - 140-170 engange (idosi 100 mg / ml). Noko ke, ichiza olungafumaneki lula nakwiikhemisti kunye nezigulane uzama ukufumana indawo. Kufuneka ngoko nangoko ithathelwe ingqalelo ezinceda oosokhemisti ngcono ekubalweni phezu umcimbi onjalo. Antibiotics angaba kuphela ngugqirha, kuthathelwa ingqalelo yesigulane imeko, ubudala, kunye comorbidities. "Azimed" uyakwazi kutshintshwa kuphela emva kokubonisana yincutshe.

Analogue ezisekelwe azithromycin yokuqala kuthetha oku kulandelayo:

1. "Ormaks".
2. "Sumamed".
3. "Zitroleks".
4. "Azivok".
5. "Asith".
6. "Hemomitsin".
7. "Azithromycin".
8. "Ziomitsin".
9. "Azitro".
10. "Azitral".
11. "Zomax."

Ngalinye emithi kubonakala zayo neempawu isicelo. Ngeyona nokulungiswa elwa inyathelo ukulungiselela unyango lwezifo ezosulelayo anganyula kuphela ngugqirha. Kuyanconywa ukuba kudlula iimvavanyo elebhu ukuqinisekisa ubukho pathogen ziibhakteriya nokujonga ubuzaza balo ukuba ichiza "Azimed". ababambeleyo Price kuya kuxhomekeka umthamo iziyobisi esebenzayo nomakhi.

"Sumamed" okanye "Azimed"?

"Sumamed" - yenye macrolide zintsholongwane-azalide. Kungomlinganiselo omncinane kunempembelelo bacteriostatic amakishiweyo. Inika amagciwane protein kudibaniso kwizisele ukuba Uxhokonxwa utshintsho kwiinkqubo pathways, kuthintela ukuzala. Okwangoku, ichiza antibacterial ngokuqhelekileyo emiselweyo kwizigulane zabantwana. "Sumamed" ubuye ezifanele ukuba unyango izigulane abadala.

"Sumamed" yakhupha inkampani Croatian zamayeza, apho kubonakala nje kuphela umgangatho kodwa iindleko beziyobisi. arhente lokuthenga inokuba ngohlobo iipilisi (125 no 500 mg), njengezingxobo gelatin (250 mg) kunye umgubo kukunqunyanyiswa yomlomo (100 no-200 mg). Analogue "Azimeda" Kwakhona iipropati immunomodulatory, ezinganxulumananga isiphumo yayo antibacterial. Iingcali zithi eli khono kungenxa impembelelo ichiza kwi cyclooxygenase kwaye ukuyilwa ion superoxide kwe-oksijini.

Zombini iziyobisi antibacterial kuba nefuthe elibi incinane microflora emathunjini. Oku kuthintela imiphumela engasi ukusuka phecana zesisu. Xa kakuhle ukufumana amayeza ayihambelani nimqumbise uphuhliso dysbiosis.

"Sumamed" zingasetyenziswa ukunyanga izigulana zincinane. tolerability ziphumo bezingalindelekanga oluncinane Good kwaye wayenza ithandwe kakhulu.

baqinisekiswa

Unyango lwezifo ezininzi ezinzulu bacinge ngaphandle antimicrobials. Kuphela ezi ndlela itshixa ikhusi ukusebenza kwamagciwane. Enye abameli isizukulwana lokugqibela macrolides ekhuselekileyo-zintsholongwane yi "Azimed".

Izimvo ezigulane kunye oogqirha bathi ukuba lunyango olusebenzayo, ube nangoko zonyango kwaye phantse akukho ziziphumo ebezingalindelekanga ezivela amalungu kunye neenkqubo zangaphakathi. Sebenzisa iipilisi okanye ukunqunyanyiswa kufuneka ibe kuphela ngengcebiso ingcali oya kubala ithamo efunekayo ye esisebenza kunye nobude unyango. Emva unyango, i-arhente elwa, izigulane ezininzi bancome unyango kwisimo ukunyenyisa microflora emathunjini.