Ichiza "Celebrex": ncomo, analogs, imiyalelo ukusetyenziswa, ixabiso

Ekubulaleni yomqolo, iintlungu eziqatha amalungu kunye nemisebenzi utshintsho kwizicwili kwisiqalo of ukudumba - ngelishwa, ezi zifo aba ixhaphakileyo ngexesha lethu. Kule meko zinje kuchaphazela yokuphila, ukungabikho umzimba oluqhelekileyo, imiba yemfuza. Ukongezelela kwintlungu kakhulu ukuba abantu bayahlupheka kule meko, isifo ekwaziyo sisonakalisa yonke ephilayo, ukutshintsha chemistry igazi ezichaphazela ukusebenza eqhelekileyo nezibilini.

Ngoko ke, kubalulekile ukujonga impilo kunye nexesha ukunyanga esi sifo. Enye amachiza kakhulu, nto leyo iba kwiqela amachiza non-steroidal ebizwa medicament "Celebrex". Izimvo oogqirha ukuqinisekisa impumelelo yayo kuthelekiswa enye amachiza-ukudumba.

Eyona Ifuthe ichiza

Inzuzo ichiza ingabizwa ngamandla ayo zinqanda umsebenzi inkqubo yokukrala kumanqanaba ahlukeneyo sifo. Xa egazini, ichiza uyakwazi ukunqanda inkqubo TSOG2 ekhokelela ukukhululeka komtshiso oko. "Celebrex" Ichiza unalo impahla iintlungu umsebenzi onamandla antipyretic. Ngoko ke, akubikho kuphela nakujoliso olutsha nangokurhala, kodwa ngokugqibeleleyo kususa nokuba intlungu eqatha, kunciphisa ifiva.

Izinto eziluncedo le mveliso ziquka ukusebenza yayo incinane zegazi, oko kukuthi, ichiza akuthethi kunokubangela iingxaki kunye igazi ekunqandeni. Xa ufumana arhente non-steroidal ukuba akukho kwinwebu esiswini namathumbu, kuyayinciphisa ingozi yokuba izilonda kunye nezigulane gastritis.

Ngoko ke, i "Celebrex" iipilisi zisetyenziswa kakhulu ngakumbi kakhulu kunokuba namanye amachiza NSAID, "naproxen", "aspirin", "ibuprofen".

zemiyalelo

"Celebrex" njengezingxobo uyakwazi ukunciphisa ubuzaza ubuhlungu bamalunga, ukuqina nya ukumelana iindumbisa ngokugqithiseleyo. sesichengeni enjalo ukunyanga izigulana kwafunyaniswa ukuba isifo samathambo, osteoarthritis. Isiphumo ichiza lufika kangangoko iiyure 24-48 emva kwedosi yokuqala. SeTrojan kweziyobisi ngempumelelo ishenxisa intlungu, nkqu kakhulu bukhali. Kwakhona, lisetyenziswa ngokuphumelelayo ukuze isiqabu intlungu emva kotyando (maxillo-zobuso kunye notyando wamathambo).

Izigulane ankylosing spondylitis iziyobisi "Celebrex" ithintela iinkqubo zophendlo lwezifo yaye kuphucula ukukwazi komzimba ukuze isebenze. Xa sigcina Dynamics kwiintsapho ukusetyenziswa polyposis adenomatous beziyobisi kwakhokelela ekuthotyweni ebalulekileyo ekukhuleni polyp kwi ikholoni kunye duodenum: nokunciphisa inani labo kunye nobukhulu. Oogqirha bathi amathamo ngokwaneleyo amayeza kunye nokubambelela iirejimeni zonyango kunokuba bazuze iziphumo ezigqwesileyo kunye nokusetyenziswa "Celebrex" iziyobisi. Baqinisekiswa ukubonisa iziphumo ebezingalindelekanga ezimbalwa ngexesha uthatha le amayeza.

Imilo kunye nokwakhiwa ichiza

Kakhulu inhibitor sikhethe capsule gelatin phantse nokuba limhlophe kanye, bengengabo ngaphaya kwaye ziphawulwe imicwe oluhlaza ezibhalwe "7767" icala elinye "100" no "200" phezu kwezinye. Philisi imixholo: granulated umbala omhlophe.

Ukubunjwa ichiza ziquka: celecoxib (Isithako esisiseko esebenzayo), lactose, povidone K30, isodiyam lauryl sulfate, nemagnesium stearate, sodium croscarmellose. Yeqokobhe wenziwe titanium dioxide, kunye gelatin ezityiwayo. Ukuba ulawulo olufanelekileyo izitofu intramuscularly iziyobisi bamiselwe "Celebrex". Olu hlobo iyeza alahlwa ngokohlobo isisombululo ukuba isitofu 2.2 ml ampoules - celecoxib basic kweziyobisi.

Pharmacokinetics

Eli chiza liye bafakwa kakuhle egazini kwi azila karhulumente kwaye ufikelela yokusebenza ubuninzi emva malunga 2-3. Nangona kunjalo, ukusetyenziswa iindlela kunye ukutya okunamafutha isenokuyilibazisa olwenzeka yayo iiyure 1-2. Ngoko kuyimfuneko ukuba udibane nogqirha malunga nexesha ukuthatha amayeza.

Ngenye egazini, izinto esebenzayo musa ukubophelela iiseli ezibomvu igazi, kodwa indlela aluchaphazeli impumelelo ingqalelo efunekayo beziyobisi emzimbeni. Drug umzimba esibindini yi igcwala kunye glucuronidation ezibandakanya CYP2C9 enzyme. Isiphumo kuthetha kunye nomchamo kunye endleni ngohlobo metabolites ezilula, no-3% kuphela into esebenzayo kuhlala ingatshintshanga.

Drug "Celebrex", analogue zazo ezifanayo kumafa, wafumana iindlela, ebangela umonakalo amancinane kwimpilo, ngenxa yokuba amandla ayo ukuba wendele kangangoko kunokwenzeka kwaye phantse neengcambu ngokupheleleyo emzimbeni. Ezinobunzima umzimba ephantsi waphawula ukuba izinga kweziyobisi egazini, yaye le nto emsebenzini ngaphezu kwabasetyhini. It akwaziwa ukuba kutheni, kodwa abantu abantsundu ndilugcinile okuhambisa efanayo. Ngoko ke, la maqela ezigulane ezimiselweyo idosi esezantsi amayeza ekuqaleni unyango.

Ubungqina obubonakalayo buxela

Njengoko a non-steroidal anti-ukudumba arhente ezenza ukuba ichiza unyango kwangumqondiso emiselweyo "Celebrex". Iimpawu zibonisa ukuba ukusetyenziswa:

• isifo samathambo;
• ukudleka;
• spondylitis;
• algomenorrhea;
• ahlekise (ixesha post-operative, iqolo, izifo musculoskeletal);
• esetyenziswa ukunyanga adenamotoznogo polyposis.

Kufuneka kuqatshelwe ukuba unyango ngokwaneleyo unganika ugqirha kuphela ngokusekelwe kuphando.

Iindlela zolawulo ichiza

Ezithatha ichiza kufuneka ngaphakathi, kungakhathaliseki ukuba ukutya. macwecwe Chewable akufuneki ukuba, kufuneka ukuba usele amanzi ethafeni. Kufuneka kuqatshelwe ukuba iingxaki sentliziyo lunokwenzeka nolawulo okondeleyo ichiza. Ngoko ke, oogqirha ukumisela "Celebrex" ikhosi emfutshane unyango. iingcali Guest ukuqinisekisa ukuba idosi iphezulu unyango ixesha elide kufuneka mayingadluli 400 mg ngosuku!

• Unyango osteoarthritis - eyaneleyo iidosi 200 mg ngamnye ngosuku. Amathuba idosi enye okanye sahlukana ibe amabini (rhoqo).
• isifo samathambo - yedosi kulindeleke 100 okanye 200 mg ka- 2 ngosuku. Xa iifom olunzima kakhulu - ukuya ku-400 mg kabini ngemini.
• Ankylosing spondylitis - 200 mg ngosuku, ngokuba amathamo 1 okanye 2 umahlule. Ngokwesigqibo kagqirha ithamo kufuneka kwandiswe ukuze kukhuseleke ngokwaneleyo
• SeTrojan kunye neentlungu strong - uqala unyango kunye 400 mg ngosuku kwaye kongezwa enye 200 mg ngosuku lokuqala unyango, xa kukho imfuneko. Kwiintsuku ezilandelayo, kufuneka uthathe mg 200 kabini ngemini.

Ubude unyango emiselwe ngugqirha khona.

Izimo ukuba ukusetyenziswa kweziyobisi

Ukongezelela ngayo kunokwenzeka bagulayo kumalungu beziyobisi, kukho imiqathango phantsi ezithintelwe ngokusebenzisa ichiza "Celebrex":

1. isifuba inyumoniya, urticaria, bayaliwa kwezinye NSAIDs.
2. Ithuba postoperative emva aortkoronarnogo badlule.
3. isilonda Peptic (exacerbation).
4. GI ukopha.
5. isifo wamathumbu arhabaxa.
6. ukusilela Heart.
7. insufficiency Severe hepatic.
8. insufficiency kwezintso.
9. Ukukhulelwa ne zisanyisa.
10. Akukhuthazwa ukuba zisetyenziswe phantsi 18.
11. Hypersensitivity ku kubahlali beziyobisi kunye sulfonamides.

Amanyathelo kufuneka asebenzise iziyobisi kunye ukugcinwa fluid emzimbeni, izifo yenkqubo sentliziyo, isifo seswekile.

imiphumela emibi

Nangona amandla eliphezulu ichiza, imo ukwamkelwa ixesha elide okanye engachanekanga idosi ukuba iziphumo ebezingalindelekanga ichiza "Celebrex". Baqinisekiswa zibonisa (rhoqo) mpawu zixhaphakileyo ezifana:

• ziyabagulisa kuquka irhashalala, urticaria, pruritus.
• Flatulence, ukuqunjelwa, nokudumba, ugwayi.
• Khohlo, nokuthimliswa, umkhuhlane-ezifana awasabela ngayo kunye nosulelo phecana zokuphefumla.
• izifo womchamo.

ngaphantsi kakhulu kukho landa ixhala, ianemia, ukuduma, ukufikelwa, arrhythmia, umfutho wegazi. Ezinye izigulane kwabhalwa izilonda phecana wokudla, nokudumba angionevropatichesky, ukuyilwa bulla kakhulu eluswini, exacerbation of pancreatitis okanye uphuhliso yayo, ukudideka. Zonke ezi mpawu kungenzeka kuphela xa ikhondo unyango ngokufutshane (ukuya kwezingama-12, engadlulanga 800 mg idosi nganye). Kodwa kwimeko kunyango ixesha elide (iminyaka ukuya ku-3) kuyagcinwa:

• Common: intlungu esitulweni, lwegazi, usulelo ngeendlebe, angina, iposi engabalulekanga, isicaphucaphu, dysphagia, prostatitis, ukwanda creatinine.
• More: arrhythmia, angina, stroke kobuchopho, yegazi, yokulala, ukopha lobufazi, izilonda emlonyeni, seTrojan, ukwanda haemoglobin, ukwehla hematocrit.

Ukusebenzisana beziyobisi kunye namanye amachiza

Le medicament ngenkuthalo biotransformed ezibandakanya P450 2C9 (cytochrome). Ngoko ke intsebenziswano kunokwenzeka ngqo beziyobisi kunye nezinye ii-arhente:

1. ukusetyenziswa ebonakalayo iziyobisi "Warfarin" kwandisa umngcipheko ukopha obulalayo.
2. Ukulungiselela "Ketanazol" yaye "fluconazole" ukwandisa uyazikhomba celecoxib into esebenzayo phantse kabini.
3. Ukwamkela blocker okanye ACE inhibitors NSAIDs angiotenzita kunganciphisa kakhulu ukusebenza antigipertinzivny lwabo
4. iimveliso kolimo equlethe lithium, oku kunganyusa kakhulu izinga igazi.
5. Akuvunyelwe ukuba ngaxeshanye ukusebenzisa i "Celebrex" analogs iziyobisi equlethe celecoxib, ezinye NSAIDs!

analogue iziyobisi

Kubalulekile ukuphawula ukuba "Celebrex" Iindleko kweziyobisi hayi kakhulu, ixabiso layo yi-avareji ukusukela ku engange-400 ukuya 450. 10 njengezingxobo (100 mg balawule). Noko ke, unyango olunjalo luyabiza ukuba unyango yomguli ixesha elide. Kulo mzekelo, kwemvume kwagqirha, iqeshe arhente equlethe celecoxib. Kuba "Celebrex" analogue kwezi zilandelayo iziyobisi:

• iziyobisi "Ranselak";
• iziyobisi "Revmoksib";
• tablets "Flogoksib";
• philisi "Artoksib".

Ezi analogs ziqulathe ukwimo enye esebenzayo yaye kunempembelelo enyangayo kakhulu twatse kwi unyango lwezifo. Qaphela ukuba idosi eyaneleyo ye-analogue nayo eyabelwe kuphela ngugqirha khona. Kulo mzekelo ugqirha ingqalelo izixhobo ezahlukeneyo composition e analogs, zinezintlu ongeziweyo ezahlukeneyo xa kuthelekiswa "Celebrex" iziyobisi. Imiyalelo kwakhona oogqirha bacebisa ukuba nokwenzeka uxabane yi isigulane excipients amayeza ezahlukeneyo kwiqela elinye.