Benzylpenicillin sodium ityuwa: imiyalelo ukusetyenziswa. imithetho isicelo

Kweli nqaku siza kuthetha amalungiselelo afana "Benzylpenicillin sodium ityuwa". Imiyalelo yokusebenzisa, izalathisi, idosi iingcebiso zokusetyenziswa ziza kuhlawulwa kweli nqaku. Ukongeza, siye siqwalasele iimpawu amayeza beziyobisi, iziphumo ebezingalindelekanga kunokwenzeka kwaye imithi kunye namanye amayeza.

iitotali

Ichiza yi-arhente elwa kunye zintsholongwane ngoweqela Lendlela Yeqela penicillin kulo. Benzylpenicillin sodium ityuwa ngokwayo, imiyalelo yokusebenzisa apho ziya thaca ngezantsi lukhutshwe zomngundo ezahlukeneyo.

Iziyobisi kweli qela asetyenziselwa ulawulo intramuscular, iziphumo izicwili ezahlukeneyo kunye namasebe apho igazi linikezela imali encinci penicillin. Ukuze ichiza waqalisa ukuba iziphumo ngobuchopho spinal nomtya kunye meninges, subarachnoid elawulwa.

Benzylpenicillin sodium ityuwa, imiyalelo zokusetyenziswa: amanyathelo pharmacologically

Ichiza kakuhle nxamnye gram-HIV iintsholongwane, ezibandakanya:

• staphylococci;
• streptococci;
• pneumococci;
• umphimbo ;
• anthrax coli;
• aerobic (ephila kungekho oksijini) sporulating iintonga.

Ngaphaya koko, eli chiza esebenzayo nxamnye Igram cocci ezimbi (meningococcus, gonococcus), spirochetes, actinomycetes kunye namanye amagciwane. Penicillin sodium netyuwa angabi nxamnye iintsholongwane, rickettsiae, nomngundo, lenyama.

ezimelene nemithi lwemithi staphylococci, ezo esikwaziyo ukuvelisa i penicillinase enzyme, disintegrating benzylpenicillin. Le medicament liveza Umsebenzi eliphantsi unyango Pseudomonas aeruginosa, iintsholongwane amathumbu kunye namanye amagciwane, ezinako ukukulumkisela yokwaba imali ezahlukeneyo penicillinase.

Pharmacokinetics

Xa ichiza intramuscular engena ngokukhawuleza egazini, ukusuka apho abalunikelwayo neencindi zomzimba kunye namalaphu. Ngokumalunga ulwelo lwe-cerebrospinal, lihlaba ukuba imali encinci penicillin. Ukufumaneka aphezulu igazi emva kulawulo layo intramuscularly kwaphawulwa emva ne30-50 imiz. Ukuba ichiza nolwathi kwesikhumba, izinga ukufunxeka luyacutheka kunye nelona nani liphezulu kwezinto egazini baza kuvandlakanywa ngeyure.

iiyure ezintathu emva kokuba isitofu (ongama okanye intramuscular) of benzylpenicillin kuphela imizila ahlale egazini. Ngoko ke, ukuze agcine yoxinaniso eliphezulu kweziyobisi emzimbeni ixesha elide, kuyimfuneko ukuba bafake ngalinye iiyure ezine.

Xa ufakwe yegazi, eyavela beziyobisi iwela ngokukhawuleza. Kwaye ngexesha uthatha ngomlomo benzylpenicillin babhubhisa penicillinase (enzyme) kunye juice esiswini.

iziyobisi kwazona kwazona kwi yokuchama.

ubungqina

Kufuneka ifundwe ngenyameko phambi kokuqeshwa neziyobisi penicillin sodium ityuwa, imiyalelo ukusetyenziswa, idosi zibonisa ukuba ukusetyenziswa. Masiqalise kunye yokugqibela. Ngenxa yoko, ichiza emiselweyo:

• kuzo izifo imiphunga kunye iphecana zokuphefumla;
• izifo nokulimala yayinzima;
• endocarditis bacteria;
• nokudumba;
• izifo kunye amanxeba esisulelweyo izicwili ezithambileyo, isikhumba kunye imifinya yangaphakathi;
• isha;
• ukudumba umnqonqo nobuchopho, neentsuba mazgovyh;
• ubovu unepleurisy;
• peritonitis;
• Ngokuzimela;
• Pius and septicemia;
• osteomyelitis;
• umphimbo;
• fever ebomvu;
• ukuvuza ngaphantsi;
• erysipelas;
• Izifo e kubelekwa;
• anthrax;
• negcushuwa;
• actinomycosis;
• inflammations ezahlukeneyo izifo;
• izifo yokukrala yomqala, indlebe kunye nempumlo.

Imigaqo yokuSebenzisa balawule

Kuxhomekeka iintlobo unyango kwesifo usebenzisa benzylpenicillin sodium ityiwa ichiza inokuba ufakwe. Imiyalelo yokusebenzisa, indlela yolawulo idosi kunokwenzeka ziya kuqwalaselwa yi kuthi kweli candelo.

Ikhosi unyango ngamachiza unokuthatha, ngokuxhomekeke sifo, ukususela kwiiveki-4 ukuya iinyanga ezi-2 okanye ngaphezulu. Ichiza inokusetyenziswa ngeendlela ezilandelayo:

• Intramuscularly kwi ikota yesangqa eliphezulu olungaphandle gluteal. Amalungiselelo liyangxengwa phambi ulawulo emanzini, novocaine okanye sodium isisombululo chloride enkolo.
• Emthanjeni - .. kuphela phantsi kwezifo ezinzima, ezifana meningitis, endocarditis ziibhakteriya, septicemia, njl Ichiza ilawulwa yonke iyure 4 okanye ukuthontsiza okuqhubekayo - 30 amathontsi ngomzuzu iiyure 6-12.
• Kusenokwenzeka kwakhona maliqhutywe endolyumbalno benzylpenicillin sodium ityuwa. Imiyalelo yokusebenzisa (indlela isicelo) inikeza indlela ngenxa ukudumba ingqondo kunye umnqonqo, kuquka meninges. Ichiza lesitofu ngokucothayo kakhulu - imizuzu 1-2.
• Kukho iimeko apho benzylpenicillin esetyenziselwa injecting le nakujoliso olutsha arhabaxa. Ngokomzekelo, xa actinomycosis, isikhumba leishmaniasis, pyoderma ezingapheliyo kunye nezinye izifo zolusu ezosulelayo.
• Nge inhalations - kuba unyango kunye nokukhuselwa kwezifo ze emiphungeni kunye yomoya. Ukulungiselela le njongo, ugalelwe sisombululo sodium chloride benzylpenicillin okanye amanzi enkolo. Inhalations akukho ngaphezu amaxesha 2 ngosuku. Olungapheliyo unyango enye - ukusuka imizuzu eli-10 ukuya kwi-30.
• Kwakhona lesitofu kwisisu pleural okanye peritoneal kwi ubovu peritonitis okanye unepleurisy.
• Xa uhlobo uhlaselwa, namafutha aqholiweyo, zokubopha efumileyo, lotions kunye Ithatyathwe emigutyeni - kuba ukutsha, amanxeba inyama ithambile, kunye osteomyelitis al.
• Kwakhona, isicombululo kweziyobisi ezisetyenziselwa ukunyanga izifo aphezulu bokuphefumla zamehlo.

Penicillin ungasetyenziswa kunyango kunye nezinye elwa amalungiselelo sulfanilamide. Enanikade indlela kuqinise isiphumo konwaywa amachiza asetyenziswa.

imiphumela emibi

Kananjalo kusenokuba nefuthe elibi benzylpenicillin sodium. Imiyalelo yokusebenzisa uphawula ukuba ziboniswa ngabaphethe efakwa beziyobisi kakhulu rhoqo.

Ngokusisiseko, iziphumo ebezingalindelekanga ezinxulunyaniswa ne kukwalisa ichiza. Olunye lweempawu ezibi lathi:

• candidiasis;
• ezindlwini;
• umkhuhlane;
• intloko;
• Ukugodola;
• ubuhlungu bamalunga;
• Angioedema;
• eosinophilia;
• iintlobo ezahlukeneyo dermatitis;
• umkhuhlane;
• lymphadenopathy;
• mothuko anaphylactic - kwiimeko ezinqabileyo kakhulu.

Izimo

Ayizizo zonke izigulane ungaya unyango kunye medicament of benzylpenicillin sodium yetyuwa. Imiyalelo yokusebenzisa kunye nemigaqo yolawulo zinika inani Izimo. Phakathi kwabo:

• izifo komzimba ezifana urticaria, hay fever, isifuba inyumoniya, njl.;
• hypersensitivity ku penicillin;
• iimpendulo engaqhelekanga nemithi;
• isifo lwegciwane ukumelana neyunithi ithamo benzylpenicillin.

Ukuqaliswa endolyumbarnym iziyobisi ekwaziyo kungavumelekile ukuxhuzula.

Ukukhulelwa ne zisanyisa

Abamiselweyo ngexesha lokukhulelwa kuphela xa isibonelelo ukuya unyango kwamabhinqa obungaphezu ingozi umntwana wakhe ongekazalwa. Kungenjalo, ichiza ayikho iphethwe. ingozi ratio kunye omhle emiselwe ngugqirha khona.

Ukuba kuyimfuneko, ulawulo ichiza ngexesha zisanyisa kufuneka uyeke ukuluncancisa.

izakhiwo

Drug kweziyobisi benzylpenicillin sodium ityuwa na uhlobo powder crystalline ecikizekileyo, emhlophe kunye incasa ekrakra apho lula enyibilikayo engamanzi.

Ichiza ngokulula yatshatyalaliswa asidi, alkalis, iiarhente oxidizing, enzyme penicillinase, ngokunjalo ukufudumeza. Lungisa into kweziyobisi mabasuswe ngokukhawuleza phambi nolawulo.

amanyathelo okhuseleko

Ichiza ilawulwa kuphela esibhedlele ngokumiselwa likagqirha phantsi kweliso lakhe. Ngenxa sicatshulwa unyango kufuneka kukhunjulwe ukuba benzylpenicillin idosi ayoneli okanye ukupheliswa okuqala onyango kungakhokelela ukuyilwa ezimelene nemithi ezincinane. Xa kunokwenzeka ukuba unyango ngamachiza ukuba kuyaqhutywa ezinye antibiotics.

Lo mkhuba negazi zilawulwa kunye isiyobisi antihistaminic kukuba benzylpenicillin sodium. Imiyalelo yokusebenzisa (isenzo beziyobisi ngokweenkcukacha yakhe ezimiselweyo ezithile) yazisa ukuba xa nangoko umguli ibonwa komzimba therapy wayeka.

Ngokwamaqela ezithile izigulane (abadala, neentsana, ngenxa yokugula) ukuze abe ukumelana benzylpenicillin, nto leyo ebangela uphuhliso superinfection.

Ezinomsebenzi elide, olwa kunokoyiswa okanye inxenye yatshatyalaliswa microflora isisu, ekhokelela ukuncipha kwemveliso kweevithamini yeqela B. Ngoko prophylactically ukuba izigulane ngokufuthi emiselweyo iivithamini B1, B12, kunye nabanye.

Ukuba, emva kokuqalisa unyango iintsuku 3 kuphunza nasonasiphi na isiphumo, kuyimfuneko ukuba uye unyango kuhlanganiswa okanye ayithiye olwa omtsha.

oyi

Amanyathelo eyabelwe abantu sisifo sentliziyo kunye nokusebenza kwezintso kakuhle benzylpenicillin sodium ityuwa. Imiyalelo yokusebenzisa ikwacebisa ukuba ingqalelo eyodwa kunikwa kwabo izigulane egcine hypersensitivity ku cephalosporins.

Ngenxa ithuba superinfection ezinzwaneni Kucetyiswa ukuba ukumisela arhente anti-ezinzwaneni.

Intsebenziswano kunye namanye amachiza

Ekuqeshweni ezo ntsholongwane, okuye bacteriostatic, isenzo bactericidal penicillin lifinyele.

Ukulungiselela "Probenecid" unalo impahla ukunciphisa secretion tubular of zintsholongwane aphelela ukwanda kwinqanaba egazini yokugqibela kwaye, ngenxa yoko, ukwandisa ixesha ukusisusa ivela emzimbeni.