"Alfacalcidol": imiyalelo ukusetyenziswa, ifom ukukhululwa, ncomo, iifoto, umthamo, analogs

Ukunqongophala vitamin D3 kunokubangela iingxaki ezinzulu. Kuba abantwana oku kusilela igcwele kuphuhliso yamathambo, ngoxa abantu abadala ukuze kulunge kukusilela unobangela kwamathambo kunye neengxaki ezifanayo.

Imarike yanamhlanje of Medicine inikeza nabathengi uluhlu lwamayeza ukuphelisa ukuswela le vitamin. Enye imithi enjalo yi "Alfacalcidol." Imiyalelo zokusetyenziswa luphawu yona njengendlela ezisebenzayo ukubuyisela imali eseleyo vitamin-bezimbiwa.

pharmacodynamics

Le medicament yi vitamin uhlobo esebenzayo D3. Ukulawulwa ngokutshintshiselana iikhompawundi kwezimbiwa ebalulekileyo, ezifana iphosphate kunye calcium, nayo inkalo ebalulekileyo iziyobisi "Alfacalcidol." Ukusetyenziswa beziyobisi iyasebenza ekuvuseleleni ekubunjweni ithambo. Inxaxheba yayo ngqo ukwanda ukufunxeka calcium phosphorus apha emathunjini kunye kwizintso. Ukongeza, eli chiza kwandisa kwezimbiwa bone lexinene ngexesha elifanayo kunciphisa inqanaba umxholo kwi PTH egazini. Ngenxa yoko, "Alfacalcidol" liye antirahitichnoe nefuthe kwaye inceda ukunciphisa inani waphuka.

Ukuba ichiza ukuthatha izifundo, koko phantsi kwempembelelo yakhe ephuculiweyo ulungelelwaniso, kunciphise ithambo kunye neentlungu kwezihlunu (zeziphi ngenxa ngokutyeshelwa calcium-phosphorus ukutya).

Kwezinye iimeko, sigwetyelwe ukusetyenziswa kweziyobisi?

"Alfakltsidol" imiyalelo ukusetyenziswa nokhokelo neengcali zonyango kucetyiswa ukuba ungayalela kwiimeko apho kukho imbali ulwazi malunga osteodystrophy, ezinganyangekiyo sezintso isigaba ukusilela. Ngaphezu koko, oko isetyenziswa hypoparathyroidism. Isizathu ngokuba yamathambo injongo, osteomalacia (ukuncitshiswa umthamo esiqwini bone) kunye ukuthambisa ithambo, uhlobo apho inokuba nomahluko kakhulu. Kwamathambo - a steroid, saka, postmenopausal - athatha with "Alfacalcidol" lithetha ngempumelelo.

Akuyonto kutyunjwa ichiza kwiimeko apho isigulane ukubandezeleka ukusuka lactic kwezintso, okanye imbali iye Fanconi syndrome (isifo ezintsonkothileyo, kuquka lactic sezintso, sithwele ilifa, nephrocalcinosis, yamathambo kunye mhlawumbi hypophyseal syndrome).

Nazo zonke ezi ngxaki, "Alfacalcidol" uyakwazi ukunika uncedo olusebenzayo.

kufuneka uyeke nini ekufumaneni?

Uluhlu Izimo ukuba ichiza iqulethe "Alfacalcidol" umyalelo manual. Iingcali Ukuphonononga angavumeli ezithatha ichiza linembali hypercalcemia lolwazi, hyperphosphatemia (ngaphandle hyperparathyroidism xa ekhula), gipermagnemii. Musa ukusebenzisa eli chiza xa kunxilwe ye ephilayo ezinxulumene nomxholo ngokugqithisileyo vitamin D3. Akuvumelekile ukuba abele "Alfacalcidol" nabondli nursing.

Kaloku, akubuzwa bathi, awukwazi ukuthatha amayeza abantu hypersensitivity ngamnye amacandelo zeziyobisi.

Izicelo and esithathwa

Ulwazi kakhulu ngokupheleleyo ukusebenzisa yaye iqulethe nomthamo nesiyobisi "Alfacalcidol" yemiyalezo ngayo. ifomu Product (njengezingxobo we 0.25 mg okanye 1), ithamo nexesha unyango ikhosi ugqirha ezikhethiweyo ngamnye ngokuxhomekeke ebukhulwini imeko yomguli kunye nohlobo sifo.

Umzekelo, izigulane abadala kunye yamathambo, okubangwa ukuswela vitamin D3, iingxaki iphecana zesisu, kufuneka afumane usuku ngesixa ithamo mg-1 ukuya ku-3. Isiphumo HIV kunye nonyango ukuze hypoparathyroidism kuxhomekeka ukususela mg-2 ukuya ku-4 beziyobisi ngosuku. umthamo ngemihla ukungaphumeleli kunye nomsebenzi osteodystrophy sezintso akufuneki idlule ubungakanani medicament ukuya 2 microgram. syndrome Fanconi kunye lactic sezintso ngempumelelo isifundo uphathwa "alfacalcidol" nomonde abafumana idosi yemihla ngemihla kwindawo umthamo 2.6 micrograms. Phambi izigulane yamathambo hypophosphatemic kunye osteomalacia olusebenzayo mali idosi yemihla ngemihla ekungabonini ukusuka micrograms-4 ukuya ku-20.

Oogqirha Sicebisa abaqala unyango kunye idosi liphantsi, esenzelwe isifo ethile ngamnye. Unyango kufuneka esweni plasma ngezinto ezifana calcium phosphorus (ubuncinane 1 ixesha ngeveki). Izikali "alfacalcidol" ukwanda kuvumelekile yi akukho micrograms ngaphezulu kwe-0.5 ngosuku. Xa ufumene umthamo omncinane wokuqalisa, umxholo ikhalsiyam egazini kufuneka ulawulo hayi ngaphantsi kwe kwiiveki 3-5.

imiphumela izigelekeqe

Njengaye nawuphi na amayeza, kukho uluhlu lweziphumo ebezingalindelekanga kwaye lithetha "Alfacalcidol." Imiyalelo yokusebenzisa (kuyahambisana, ngokuzenzekelayo, ngokunjalo neziphumo ezifanayo) kuzisa imfutshane bonke izigulane ukuba ichiza kungaba asabela kwinkqubo yokwetyisa. Kwiimeko ezininzi, isicaphucaphu, ukugabha, iintlungu epigastric, ukuqhina okanye isifo sorhudo, heartburn, imvakalelo kome inwebu yangaphakathi emlonyeni. Ngaba kubonakala anorexia.

CNS iziphumo ebezingalindelekanga zingenzeka ubuthathaka jikelele kunye ukozela, ukudinwa, intloko ebuhlungu kunye nesiyezi. Ngamanye amaxesha izigulane zithi malunga uphuhliso tachycardia (izinga lentliziyo ngokukhawuleza) kwaye ukunyuka koxinzelelo lwegazi. reactions Dermatologic ekunokwenzeka ukurhawuzelela kunye irhashalala kakhulu eluswini, hayi uphuhliso olumandla kakhulu ngethambo, izihlunu kunye neentlungu ezidibeneyo. Zisenokwahluka ngandlel amaxabiso laboratory malunga lipoproteins ngaphezulu lwetshiphu emsebenzi-mninzi. Kukho amathuba hypercalcemia, hyperphosphatemia (abo bathwaxwa ezingaqhelekanga kwi nokusebenza izintso).

ngeedosi kakhulu

A Inani ngezenzeko lokukhabayo linokunikwa iqatshelwe isiganeko yadlula kuvumelekile ukuba "Alfacalcidol" balawule iziyobisi. Imiyalelo yokusebenzisa esimele izigulane malunga nengozi yokuba nesifo hypervitaminosis D. iimpawu libanda Early zibangelwa hypercalcemia. Ukususela yaqaqamba aqaqambe naziphi reactions kunokwenzeka zesisu, iintlungu kwezihlunu, into ebuntsimbi incasa emlonyeni, ukudinwa.

Xa ukunxila ezinganyangekiyo izigulane ingxelo ukozela kunye yintloko Inokwenzeka ubuthathaka, ukuba nochuku, sokulibala, inkumbulo ongaboniyo, kwaye ukunyuka okungephi uxinzelelo lwegazi. Xa nokwakhiwa igazi ngamanye amaxesha iqulethe izixa intsalela ye-nitrogen kunye creatinine. Kukho ingozi hyperemia conjunctival, calcification iimpahla zezintso, umphunga, ithambile inyama negazi, ukuyilwa of concretions kwi nezintso. Kubekho iingxaki ilizwi (hoarseness) kunye.

Ukunciphisa iimpembelelo i libanda, le amayeza kufuneka zipheliswe, isisu ayihlambe, nika, kuxhomekeke iimpawu womchamo ngokwenzekayo, bisfofonaty, olugqitha esikhumbeni usebenzisa izisombululo ephantsi becala ngecalcium.

Imida beziyobisi

Kukho inani lezifo apho kuyimfuneko ukuze anyamekele 'Alfacalcidol. " Imiyalelo yokusebenzisa acetyiswayo ukuba aphathe kakuhle imeko yabo yempilo kwizigulana ukubandezeleka ngenxa yegazi, sarcoidosis (okanye nayiphi na enye granulomatosis iintlobo), isifo sephepha yemiphunga (isigaba esebenzayo), sisifo sentliziyo kunye nomsebenzi insufficiency kwezintso (ifom ezingapheliyo). Yiba abele Lumkela "Alfacalcidol" ukuba iimpawu nefrourolitiaza nomonde. Abantwana kunye nezigulane asebekhulile nabo basengozini (ichiza yokugqibela akwazi ukunika amandla okuqhubela phambili kuphuhliso yamafutha).

Ukukhulelwa ne zisanyisa

Ke bona abafazi abakhulelweyo kunye mame i "Alfacalcidol" umyalelo ivumela ukuba asebenza kuphela kwiimeko apho isiphumo kulindeleke elincumisayo unina ngaphezu ubungozi kwimpilo yophuhliso usana kunye.

Hypercalcemia kwi umama okhulelweyo, wamqumbisa ngokusebenzisa ixesha elide "alfacalcidol," kunganika ukutyhala kuphuhliso kukho iqela leengxaki olungekazalwa. Sezifo zimandundu umntwana ongekazalwa ingabizwa hypersensitivity ukuya ivithamin D, ingcinezelo ukusebenza nobubovu parathyroid, stenosis aortic, ukukhubazeka engqondweni, elfopodobnoy ethile ebonakalayo syndrome.

Ukongezelela, "Alfacalcidol" imithamo ezincinane ekwaziyo ngexesha zisanyisa kwazona ngobisi lwebele. Ukunqanda umngcipheko iimpawu hypercalcemia emntwaneni, kubalulekile ukuba ngendlela amayeza ngononophelo.

Intsebenziswano kunye nezinye izinto

"Alfacalcidol" Umsebenzisi Application siyaleza ukwamkela ngaxeshanye kunye anticonvulsant (barbiturates, phenytoin, njalo njalo. D.) Ngenxa yokwanda ( "alfacalcidol") ukutya kwayo. Impembelelo inhibitors esahlukileyo. Ukusetyenziswa koMgaqo-medicament ngokudibene arhente eziqulathe digitalis, kungabangela ukuphuhliswa arrhythmias.

Ngokuphawulekayo kunciphisa ukufakwa "alfacalcidol" ngokunxuseneyo nokwamkelwa wayo albumin, asidi, ioli izimbiwa, colestipol, colestyramine, sucralfate.

Indibaniso laxatives wemagniziyam aqulethe okanye asidi, lwandisa amathuba gipermagniemii okanye giperalyuminemii. Ekusebenziseni i "alfacalcidol" ngamayeza, ukuba ukwakheka uVithamin D okanye nayiphi avela kulo, kwandisa ingozi hypercalcemia.

imiphumela abanetyhefu "alfacalcidol" leyo kakhulu zancitshiswa ngokunxuseneyo ngayo isicelo of tocopherol, ascorbic acid kunye pantothenic acid, thiamin, riboflavin, vitamin A. Umphumo sesichengeni "alfacalcidol" ingaphantsi iqapheleka phambi avela kunye etindronoy pamidronic acid, glucocorticoids, kaltsitona. Ukongeza, eli chiza okuvuselela kukufakwa izinto phosphorus aqulethe, nto leyo eyandisa amathuba yokuvela hyperphosphatemia.

amachiza afanayo

ngokubanzi ekhoyo "Alfacalcidol" analogue kweziyobisi kwimarike zoxubo kweli lizwe. Imiyalelo zokusetyenziswa iqulethe ulwazi abo kakhulu. Ezi ziquka iziyobisi "Etalfa", "Alpha-D3 Teva", "Ca-Alfadol", "alfa-Wang", "Oksidevit", "Tevabon".

Ezi abavelisi machiza ewusondeza abathengi neendlela ngeendlela: iipilisi kunye njengezingxobo gelatin, ilahla kunye nomgubo, izisombululo ukumnika efakwa.

Izimvo elungiswa "Alfacalcidol"

Naliphi na ichiza ixhaswa kunye iqela, kanye njengokuba kunjalo amalungiselelo "Alfacalcidol." Imiyalelo yokusebenzisa, iifoto izigulane anelisekile kunye nempembelelo ezwi kwi umzimba, yenza kucace ukuba abathengi ukuba ichiza sinako ukuphucula kakhulu umgangatho umntu bobomi kunye nenani izifo ezinxulumene ne ukuswela iivithamini kunye neeminerali, nethe ikhalsiyam-phosphorus. Ukongezelela, "Alfacalcidol" uyakwazi ukuphucula nje imeko iinwele kunye nezikhonkwane, nto leyo nayo ibalulekile.

Ezinye izigulane abanganelisekanga nesibakala sokuba "Alfacalcidol" asikwazi zingathengwa kwimarike ezivulekileyo, njengoko ufuna amayeza evela kugqirha. Nangona kunjalo, abasebenzi bezempilo banoluvo lokuba amalungiselelo ezinzulu ezinjalo, yaye kufuneka zifikeleleke kuye wonke ubani.