"Propranolol": analogue, imiyalelo ukusetyenziswa, inkcazo kunye nohlolo

"Propranolol" - iyeza ngoweqela of blocker uyakhetha. Eli chiza lineziphumo antianginal, antiarrhythmic iqinile. Le medicament elawulwa ngenjongo yokuba ukunyanga isifo sentliziyo kobuchopho, thyrotoxicosis, lwegazi. Amayeza iyasebenza neuro DYSTONIA, migraine. Lusetyenziswa ekuphumezeni unyango ukungaphumeleli kwentliziyo, sifuba angina. Ichiza bazuze umzimba iposi engabalulekanga. Athatha arrhythmia kunye cardiomyopathy hypertrophic. Xa isigulane ayifaneleki "Propranolol" isasetyenziswa zigqalwa prescribers eyodwa ukuba isigulana kangangoko.

release Form

Unako ukuthenga iintlobo ezimbini iziyobisi - iziyobisi "Propranolol" kunye neziyobisi "Propranolol Nycomed". Oku efanayo amayeza ziveliswa abenzi ezahlukeneyo amacwecwe.

Amacandelo beziyobisi

Amalungiselelo senziwa ngokususela propranolol kweziyobisi esebenzayo. Ulapha ingxenye main inokuba nomahluko - 10, 40, 80 no-160 mg kuhlanganiselo tablet nganye.

izithako Auxiliary ezisetyenziswa xa kusenziwa iipilisi zahlukile kwaye lixhomekeke abenzi. Bazi ukuba yintoni na amayeza phambi kokuba usebenzise kuyimfuneko ukufunda manual.

Isiphumo konwaywa ichiza

Ibonisa ukukwazi ukuvala receptors beta-adrenergic lithetha "Propranolol" umyalelo manual. Analogue nawo umzimba ofanayo isenzo. Macwecwe nefuthe nemithambo beta receptors iindonga 1 no 2. Isiphumo inhibitory kwezi receptors kukhokelela ukunyenyiswa yeendonga semithambo, ngaleyo ndlela asuse ezininzi iingxaki - uxinzelelo lwegazi oluphezulu, ukwanda kwemfuno kwentliziyo zokufumana ioksijini, ubonelelo amahlwempu izondlo neoksijini ukuze ancedisana amalungu.

isenzo Antiarrhythmic beziyobisi ikhuthaza yimbonakalo utshintsho HIV emzimbeni, ezifana sinus node ukuzenzekela ukuzinza, ukunciphisa Uhanjiso node atrioventricular, ukupheliswa eyandileyo excitability lweeseli ukuba abe myocardium. Enkosi kwi "Propranolol" wambuyisela ukusebenza okuqhelekileyo intliziyo, akukho yokusabela kwizinto yangaphandle, nto leyo enokuchaphazela kakubi rhythm yayo.

"Propranolol" analogue ukukhuthaza uphuhliso legalelo anti-anginal leyo ebonisa imo oluphuculweyo zihlunu kwentliziyo, ukunciphisa ubungakanani oxygen ezifunekayo ukusebenza kwawo. Oku kuthetha ukuba intliziyo ifuna ioksijini ngaphantsi kufuneka licuthwe, kwaye rhoqo kwezi izishunqulelo leyo kakhulu lincitshiswe.

isenzo iqinile isekelwe ukwanda mithambo kwemithambo yegazi kunye ukunyenyiswa kweendonga zawo. Ukusetyenziswa nedosi enye amacwecwe kukhokelela ekunciphiseni uxinzelelo lwegazi, isiphumo kubangela zigcinwa ubuncinane iiyure ezingama-20 ebusuku. ukusebenza Esitalini iqinile yabonwa emva kweeveki ezimbini ukusetyenziswa rhoqo iipilisi. Ichiza olubalulekileyo kodwa isiqabu kweemeko lukhatshwe kukunyuka okukhwankqisayo uxinzelelo, kubonisiweyo ukuba unyango lwexesha elide lwegazi.

iziyobisi ukusetyenziswa Long-term kukhokelela kuphuhliso neziphumo cardioprotective. Bonisa ukuhla amathuba ukwenzeka iposi engabalulekanga emva unyango olunjalo lithetha "Propranolol" ncomo, imiyalelo. Ngokuphawulekayo kuyayinciphisa ingozi yokufa ngesiquphe yenzeke. Yinto eyaziwayo ukuba chiza nemiphumo emihle ngamandla ephakamileyo intraocular.

Pharmacokinetics

Emva kokuba ngaphakathi kwindawo engundoqo umzimba ako iziyobisi (malunga 90%), lo gama kwisalathiso bioavailability ayinamsebenzi. Unxibelelwano kunye neeproteni esihambelanayo kwi 93%. Drug emzimbeni liyasuswa umchamo, eziwa metabolites. iintlobo Constant iye ngaphantsi kwesinye ekhulwini amayeza.

ubungqina

"Propranolol" analogue umyalelo ikuvumela ukuba unikeze unyango iimeko ezithile kunye nezifo. Bona ngayo lwegazi portal kunye emithanjeni, muscular engabalulekanga, hyperthyroidism. Imithi inceda lula meko sayo iingqameko le aorta, lafa kubalulekile, uphaphazele, ingasetyenziswa njengesixhobo zisetyenziswe prophylaxis of migraine. Amacwecwe ezifanelekileyo unyango entliziyweni Ijoni, iposi engabalulekanga, arrythmia. Ichiza yenziwa izigulane mitral valve prolapse. Izenzo ezibonisa ziquka tachycardia supraventricular kunye sinus. Nokwabela kuthetha belusenziwa syndrome ukurhoxiswa, sifuba angina, akathisia, ezivela ngenxa yokusetyenziswa neuroleptics. Amayeza emiselweyo ukuba izigulane pheochromocytoma ukulapha udibaniso. Ichiza isetyenziswa ngobuthakathaka umsebenzi yabasebenzi emva exesheni ukuphelisa obubonakala ezimbi.

Izimo

Kukho ezinye Izimo for "Propranolol" iziyobisi. Analogs kungaba ukhethe kwiimeko apho ichiza ayifaneleki. Izimo ziquka:

• nobandlululo kuthetha amacandelo;
• yashiya cardiogenic;
• bradycardia, apho inani zisaphila ngomzuzu ngu 55 sp.;
• lactic metabolic;
• Ukungaphumeleli intliziyo ezinganyangekiyo okanye iifom oyingozi;
• vasomotor nokuthimliswa;
• ibloko sinoatrial, atrioventricular (2, isidanga 3);
• angina Prinzmetal ;
• wegazi;
• Sebenzisa insulin;
• syndrome kuhambisane sinus;
• ixesha phambi ngexesha apho ngokuzila langoku ixesha elide;
• iingxaki namaphephandaba peripheral (decompensation inqwanqwa);
• zidluliselwe ngaphambili isifo nkongomiso apho abachaphazelekayo yomoya, isifuba, ukufumaneka bronchospasm.

Kukho iimeko apho kufuneka isilumkiso. Kule meko zilandelayo, ungakhetha endaweni ichiza "Propranolol" analogue, izithethantonye:

• myasthenia gravis;
• seswekile (decompensated, subcompensation);
• umsipha wentliziyo insufficiency (asthma), isibindi, intso;
• besisu yiSpasticity;
• ukudana;
• ibloko atrioventricular (isidanga sokuqala);
• ukhwekhwe;
• ukwanda umsebenzi ingaba lengqula;
• iintlobo ezingapheliyo yomoya;
• iswekile eliphantsi igazi;
• emphysema;
• ebudaleni;
• Ngexa lokukhulelwa, breastfeeds.

unyango ngamachiza

Izigulane lwegazi kufuneka athathwe idosi kweziyobisi kabini yonke imihla mg 40 nganye idosi enye. indyebo yayo kunokwenzeka kwiintsuku 14-28. Ukuba kuyimfuneko, tablets ndingasela yemihla ngemihla kwindawo umthamo mg 80 ukuya 160. Njalo indlela abafumana iyafana.

Xa tachyarrhythmia izigulane abadala basela izihlandlo ezithathu okanye ezine yonke imihla ukususela-10 ukuya kuma-30 mg yokwamkela nganye "propranolol" ithetha. ingasetyenziswa Analogs, ukuba le mveliso xa inganeli. izigulane abancinci kunye nengxaki efanayo ka iziyobisi alawulwa ngendlela imali ukususela mg 0.2 ukuya 0.4 ubunzima bomzimba ikilogram. Esi rhoqo Isicelo kuthetha - njengoko kathathu okanye kane ngemini.

Njengenyathelo lokuthintela kwizigulane abaqatshelwe angina amisele ezine ukuthatha eli amayeza yonke imihla. A idosi enye ye- mg-20. indyebo yayo kunokwenzeka iintsuku ezisixhenxe. 40 mg of ichiza kuthathwa ngezinga elifanayo, 80 mg - kancinane ngaphantsi rhoqo (kabini).

Emva engabalulekanga iposi prophylaxis ezifunekayo. Uyiqhuba njani medicament "Propranolol". Ubukhulu idosi efanelekileyo enye i-40 mg, le imisitho kweziyobisi ngamnye ngosuku kufuneka ufakwe ezintathu. Yandisa ithamo de ubuninzi mg 80.

amanyathelo Migraine othintelo kufuneka wadibana ukusetyenziswa kwe-40 mg beziyobisi kabini ngemini. Dinga ukwanda ithamo ku-80 mg, ngokuthatha amayeza yonke imihla babe babini, mhlawumbi bathathu, kwaye abantwana - abathathu okanye abane. Ukubalwa ithamo izigulana amancinci lwenziwa ingqalelo ubunzima babo, ngekhilogram nganye - ukusuka kwi 1.5 ukuya 2 mg.

Thyrotoxicosis - isifo apho ichiza unikwa 10 mg kodwa hayi ngaphezulu kwe-40 ukuze bafumane kathathu okanye kane ngemini.

Ukuba uceba kuthomalaliso pheochromocytoma, ichiza kudityaniswe blocker alpha.

imiphumela emibi

Ukuba sinikele ingqalelo koko imisela iziphumo ebezingalindelekanga iziyobisi "Propranolol" umyalelo manual. Analogs reviews - ayikho ingcaciso ebaluleke kakhulu, eziphembelela ukhetho lwamayeza unyango. Esichengeni reactions ebuhlungu umzimba ezincinane, oko kuyimfuneko ukufunda ngenyameko imiyalelo, kubalulekile ukuba simazi.

Amayeza ukuba zisetyenziswe ngendlela engafanelekanga banokubenzakalisa nemithambo yegazi ebangelwa yokuphazamiseka kwinkqubo luvo, inkqubo yonyango. obubonakala kunokwenzeka elibi inxalenye wokugaya, ukuze ukuphazamisa inwebu yangaphakathi kunye nesikhumba. Phakathi imiphumela emibi adweliswe imiyalelo - neengxaki zokuphefumla. Kusenokubakho ezinye iziphumo ebezingalindelekanga.

ixabiso Analogs

Phambi kokuba uthenge "Propranolol" analogue ichiza, ixabiso idla bafunda izigulane. Thenga iipilisi kunga 16-75 engange. Ixabiso iya kumiselwa inani amacwecwe pack nganye. Buyisela ichiza kunokuba "Propranobene" imithi "obzidan" okanye "Inderal". Unakho ukwenza unyango "Inderalom LA", "Inderalom".

Ngokubhekiswa "Propranolol" imiyalelo iziyobisi ukusetyenziswa, ixabiso, analogs zinika ingcaciso ebalulekileyo kunceda ukwenza isigqibo kakuhle xa ukhetha amayeza kunye nonyango.

reviews

Uhlaziya becala HIV. Babika ukuba unyango ngamachiza evame ukuphumelela. Ukongezelela, abaninzi wanelisekile amayeza ngexabiso eliphantsi. "Propranolol" uyakwazi ukugcina uxinzelelo lwegazi kwinqanaba eqhelekileyo, ngokukhawuleza sizohlukana iyangongoza intliziyo. Amayeza kunciphisa iimpawu zesifo sentliziyo, ephelisa iimvakalelo zabantu. izimvo ezingalunganga ngesiqhelo abantu bahambe ngenxa yeziphumo ebezingalindelekanga ezimandundu ezinokuthi zenzeke ngexesha unyango. Maxa wambi kukho ubuthathaka kakhulu, usokola ukulala, amabi.