Imidazoliletanamid pentandiovoy acid: inyathelo amayeza, isicelo, analogue

Ukuba ugqirha wakho unesifo i "igciwane lohlobo", oko kuthetha ukuba kufuneka aphathe kakuhle. Iqela enkulu kangangoko nengenzulu abemi bethu bakholelwa ukuba antibiotics - iyeza ilungileyo zonke izifo. Ngelishwa, yinto engachananga ukwenzakalisa okuninzi ngaphezu sifo elililo. Antibiotics bakhuthele kuphela izifo yintsholongwane, kodwa ke azinawo amandla neentsholongwane.

Indlela imisebenzi iziyobisi?

Kukho kakhulu inani elikhulu kweziyobisi kunye nomsebenzi antiviral. Enye izinto kwemininzi eqhelekileyo ukuba olu impahla - it imidazoliletanamid pentandiovoy acid.

Iyasebenza xa ulele iintlobo influenza A no B, adenovirus, parainfluenza kwaye inceda yokuphefumla syncytial usulelo ntsholongwane.

Le umchiza iyakwazi ukukunyanzela elikhethekileyo amanyathelo. It abangaphangeliyo inkqubo okuzala kwisigaba isigaba iintsholongwane kernel kwaye retards yokufuduka arhente osanda ezosulelayo ukusuka iiseli bume isiqalo cytoplasmic.

Kwakhona pentandiovoy imidazoliletanamid iasidi babandakanyeke kumajoni omzimba womntu, ngokubonelela isiphumo modulating. Le into kwandisa igazi interferon isiqulatho inqanaba eqhelekileyo nokomzimba. Kwakhona kukhuthaza inkqubo, γ-interferonproduktsii leukocytes α-, nto leyo zikwimeko ohambelana yale misebenzi.

Uphando osisiqu esebenzayo wabonisa ukuba imidazoliletanamid pentandiovoy acid ikhuthaza ukuveliswa cytotoxic lymphocyte amanyathelo. Ngaphezu koko, oko kwandisa inani NK-T-arhente ukuba ube nekhono nanto ukutshabalalisa iiseli satshintshwa iintsholongwane, kwakunye isenzo ngqo kwi ngamagciwane.

Unalungelo lini na ke phambi ichiza waba iipropati anti-ukudumba. Bona enikwa abathintela imveliso profile cytokines, kwakunye nokuhla umsebenzi lo myeloperoxidase enzyme.

ukusebenza therapeutic

Imidazoliletanamid pentandiovoy acid, izimvo zazo HIV, le elandelayo ibonisa isiphumo kwezonyango kwi unyango SARS kunye neAvian:

• Oku kunciphisa ixesha inkqubo febrile.
• Kunciphisa iimpawu kunxilwe (nesiyezi, iintlungu, ubuthathaka).
• Kunciphisa kubonakaliswa catarrhal.
• Kunciphisa ezinobuzaza lo kugula.
• Kunciphisa ixesha lokugula.

Iziyobisi kunye imidazoliletanamidom pentandiovoy acid

Kwikhemesti efumaneka kuzo le nemixube zilandelayo equlethe imidazoliletanamid pentandiovoy acid:

• "Vitaglutam" emigutyeni.
• "Ingavirin" ngohlobo njengezingxobo.
• "Dicarbamine" iipilisi.

Izimo

Njengayo nayiphi imidazoliletanamid isiyobisi pentandiovoy acid - ichiza kufuneka uqhutywe ngaba ugqirha khona. Le imveliso amayeza iye Izimo, kuquka:

• Ngethuba lokukhulelwa zisanyisa.
• Abantwana ukuya kwiminyaka engama-18.
• Hypersensitivity kwezakhi iziyobisi.

ziziphumo ebezingalindelekanga ezivela kwiyeza equlathe into esebenzayo echazwe lungabonakaliswa ngohlobo uxabane nawo.

Le isiphumo inikwa ukuba umntu uvakalelo ngamnye ukuba imidazoliletanamidu pentandiovoy izinto acid okanye abangabancedani, eziyinxalenye beziyobisi.

ukuphepha

Abanye abantu bazama ukuthintela ukusetyenziswa kweli chiza, ekholelwa ukuba imidazoliletanamid pentandiovoy acid - yinto olwa nawo. Le mbono nto bayikholelwayo, ekubeni le into esebenzayo ebonisa umsebenzi antiviral kuphela. umgangatho ebizwa ahluthwe kuye zonke iziphumo ebezingalindelekanga ukuba ikhona elwa profile iziyobisi. Eli chiza akukho senzo immunotoxic, umhlaza, njengoko ipapashwe okanye allergenic ngaphandle ukubacaphukisa wokugaya hayi kuyacuthwa umsebenzi ekuzaleni akukho embryotoxic okanye ukusebenza yaManzi naMahlathi.

Ziphawulwa nge umsebenzi kunokuba ephezulu iziyobisi iqanjwa imidazoliletanamid pentandiovoy analogs iasidi ezithathwayo ngomlomo. Bona baphilela ngokukhawuleza kwi phecana zesisu yaye ngokulungelelana athunyelwa Amalungu nezihlunu. Kakade emva isiqingatha seyure emva kokungenisa le nto amayeza ifikelela ubuninzi eyavela egazini yaye yabamba iiyure 37. Ubude unyango iintsuku ezi-5. ulawulo ngalinye ichiza Jump umxholo wayo egazini, leyo kunciphisa kancinci emini. Ichiza emzimbeni womntu umzimba ayitshintshanga yi izintso kunye namathumbu output.

reception feature

Kubalulekile ukujonga ukuba idosi lwemithi ichiza. Imidazoliletanamid pentandiovoy analogs acid luphawulwa malunga isiphakamiso enye ukusetyenziswa, ziphele ngomlomo kanye ngemini isixa-90 mg kwithuba leentsuku 5-7, kungakhathaliseki ukuba ukutya.

Le peculiarity yale kunyango arhente zamachiza kukuba ukusebenza komkhulu kuphunyezwa xa kunikwa emva uzingela Iimpawu zokuqala zesi sifo kwisithuba seentsuku ezimbini zokuqala.

"Vitaglutam" - umthombo qela arhente antiviral

Imbali ichiza kufuneka sibuyele 70s zenkulungwane lokugqibela. It siqulunqwe odumileyo Russian igqirha pulmonologist Alexander Chuchalin. Le medicament iquka njengoko koyintloko esebenzayo nto imidazoliletanamid pentandiovoy acid. "Vitaglutam" yaqaliswa phantsi igama lorhwebo "Dicarbamine" de-2008. Injongo yakhe yayikukuba, ukukhuthaza inkqubo hematopoiesis kubaguli abaye unenzondelelo unyango unyango lomhlaza.

Ngo-2009, abantu lijongene embi usulelo virus - flu, okanye A / H1N1. Ngelo xesha, "uphuhliso Vitaglutama 'ziye afanelekileyo kakhulu. Aleksandr Chuchalin, lowo ngelo xesha ugqirha oyintloko Russian Federation, wagqiba ukuvavanya indalo yakhe intsholongwane flu kwaye sele iphumelele iziphumo ngempumelelo. Wathi ukuba imveliso yasekhaya, olusekelwe imidazoliletanamid pentandiovoy acid, "Vitaglutam" ubonisa ngempumelelo enkulu kakhulu kusulelo enamandla imveliso zoxubo American "Tamiflu". Yena ngenkuthalo ihlanganiswe ufuzo wentsholongwane egazini, latyhaphaka.

Ubomi Entsha "Vitaglutam" iziyobisi "Ingavirin"

Chuchalin ecetywayo Gennady Onishchenko, ugqirha oyintloko yococeko ye-Russian Federation, ukusebenzisa wokusungula njengesixhobo ngempumelelo unyango flu. Ngenxa yoko eyiyo yolingo lwezonyango beziyobisi sele lwenziwe, apho kuqinisekiswa impumelelo yayo ngokubhekiselele izifo ezahlukeneyo wentsholongwane egazini. Ichiza wanikwa igama elitsha "Ingavirin" kwaye ubhaliswe kwirejista zelo qela iziyobisi antiviral kunye immunostimulatory.

Xa le mveliso yinkampani yamayeza "Valenta" waya yokuthengisa, kuphakanyiswe ngokusesikweni i-Ofisi yoMphathiswa wezeMpilo njengonyango lwe-flu kunye yambetha iirekhodi baduma phakathi kwabantu. Ngenxa yoko, nathi sithi malunga ukufana "Dicarbamine" - imidazoliletanamid pentandiovoy acid - "Vitaglutam", oko kukuthi, enyanisweni, enye amayeza efanayo.

Kubalulekile ukuphawula ukuba "Ingavirin" wangena ezithengiswayo 2008 ngaphandle izilingo ezipheleleyo lwezonyango. Ngenxa uncedo Onishchenko ngo-2009 olungongezwanga kwiimvavanyo zeklinikhi kwi mpuku zelebhu ahlelwa. Kwakhona kule siganeko, kuyo izigulane malunga 100 inxaxheba. Ngokusekelwe kwiziphumo Iqela elifundayo kwakhokelela Chuchalin wagqiba kwelokuba "Ingavirin" kwisithuba seeyure ezingama-48 ukususela ekuqaleni losulelo wabonisa kwamagciwane isifo ngobuchule eliphezulu. wesenzo kubonakaliswe ukuncitshiswa kwexesha febrile, ukuhla zinetyhefu izilwanyana elebhu kunye nezigulane nokunciphisa kubonakaliswa catarrhal.

Ngoko ke, akukho sizathu sokuba bacinge imidazoliletanamid pentandiovoy acid ukuba dummy - impumelelo yayo kufunyaniswe ngokwezonyango.

"Dicarbamine" namhlanje

Okwangoku, zonke zontathu iziyobisi ngokwesiseko imidazoliletanamida pentandiovoy acid ngokorhwebo zikhona yaye kubekwe olufanayo nabantu omnye komnye.

"Dicarbamine" ekucetyiswa ukuba zisetyenziswe izigulane kunye nobukho yamathumba amabi. Ukongeza eyona nto ephambili esebenzayo, iqulathe ubisi iswekile, talc, iitapile starch, nemagnesium stearate, isisombululo colloidal of lesilicon dioxide kunye stearic acid.

"Dicarbamine" liye iziphumo zonyango zilandelayo:

• Ekukhawuleziseni neutrophil iyantlukwano ekukhuleni esebenza.
• Gematoprotektsiya kunye chemotherapy myelosuppressive.
• Ukunciphisa nezihlandlo ukwenzeka neqondo neutropenia ityhefu, leukopenia umda.

Le amalungiselelo Kucetyiswa ukuba isicelo phakathi izifundo nechemotherapy.

impumelelo yalo sele kubonakala emva kweentsuku 21-28 wolawulo yonke imihla iipilisi.

A idosi enye ye- amayeza - 100 mg (1 tablet) - sathathwa kwiintsuku ezi-5 phambi kokuqala ichemotherapy kunye kwaqhubeka kulo unyango. "Dicarbamine" na ipropati ukukhuthaza kunaba intshukumo amachiza cytotoxic anticancer, ukunciphisa iziphumo zinetyhefu kakhulu cyclophosphamide kunye neziyobisi ezisekelwe platinum, kunye nesiphumo kwiinkqubo eqhelekileyo hematopoiesis.